Sunitinib Plus Prednisone In Patients With Metastatic Castration-Resistant Prostate Cancer After Failure Of Docetaxel Chemotherapy

NCT ID: NCT00676650

Last Updated: 2013-03-08

Study Results

Results available

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

873 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-07-31

Study Completion Date

2011-12-31

Brief Summary

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This study will compare the safety and efficacy of sunitinib in combination with prednisone versus placebo and prednisone in patients that have metastatic castration-resistant prostate cancer that has progressed after treatment with a docetaxel-containing chemotherapy regimen. This is a second-line study.

Detailed Description

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Conditions

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Prostatic Neoplasms

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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A

Treatment Arm A - sunitinib + prednisone

Group Type EXPERIMENTAL

Prednisone

Intervention Type DRUG

5 mg BID, oral

sunitinib

Intervention Type DRUG

37.5 mg/day, oral, administered on a continuous daily dosing regimen

B

Treatment Arm B - placebo + prednisone

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

37.5 mg/day, oral, administered on a continuous daily dosing regimen

Prednisone

Intervention Type DRUG

5 mg BID, oral

Interventions

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Prednisone

5 mg BID, oral

Intervention Type DRUG

sunitinib

37.5 mg/day, oral, administered on a continuous daily dosing regimen

Intervention Type DRUG

Placebo

37.5 mg/day, oral, administered on a continuous daily dosing regimen

Intervention Type DRUG

Prednisone

5 mg BID, oral

Intervention Type DRUG

Other Intervention Names

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Deltasone Sutent, SU011248 Deltasone

Eligibility Criteria

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Inclusion Criteria

* Histologically or cytologically confirmed adenocarcinoma of the prostate.
* Progressive, metastatic castration-resistant prostate cancer after failure of docetaxel chemotherapy (resistant or intolerant).
* Progressive disease based on PSA progression, RECIST, or positive bone scan.
* ECOG 0 or 1.

Exclusion Criteria

* Prior treatment with sunitinib and/or more than 1 prior chemotherapy regimen in the metastatic disease setting.
* Chemotherapy within 3 weeks.
* Impending complications from bone metastases.
* Ongoing urinary obstruction.
* Cardiac dysfunction, QTc \>470 msec.
* CNS involvement.
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Decatur, Alabama, United States

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Huntsville, Alabama, United States

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Huntsville, Alabama, United States

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Anaheim, California, United States

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Encinitas, California, United States

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Glendale, California, United States

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La Jolla, California, United States

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Los Angeles, California, United States

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Modesto, California, United States

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Thousand Oaks, California, United States

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Thousands Oaks, California, United States

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Vista, California, United States

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Westlake Village, California, United States

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Denver, Colorado, United States

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Lafayette, Colorado, United States

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Gainesville, Florida, United States

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Orlando, Florida, United States

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Winter Park, Florida, United States

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Arlington Heights, Illinois, United States

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Niles, Illinois, United States

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Winfield, Illinois, United States

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Zion, Illinois, United States

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Carmel, Indiana, United States

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Fishers, Indiana, United States

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Greenfield, Indiana, United States

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Indianapolis, Indiana, United States

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Indianapolis, Indiana, United States

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Lafayette, Indiana, United States

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Louisville, Kentucky, United States

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Boston, Massachusetts, United States

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Danvers, Massachusetts, United States

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Minneapolis, Minnesota, United States

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Saint Cloud, Minnesota, United States

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Corinth, Mississippi, United States

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Southaven, Mississippi, United States

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Lincoln, Nebraska, United States

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Omaha, Nebraska, United States

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Henderson, Nevada, United States

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Henderson, Nevada, United States

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Las Vegas, Nevada, United States

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Sewell, New Jersey, United States

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New York, New York, United States

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The Bronx, New York, United States

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The Bronx, New York, United States

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Cary, North Carolina, United States

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Durham, North Carolina, United States

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Kernersville, North Carolina, United States

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Lexington, North Carolina, United States

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Mount Airy, North Carolina, United States

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North Wilkesboro, North Carolina, United States

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Bismarck, North Dakota, United States

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Cleveland, Ohio, United States

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Mentor, Ohio, United States

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Westlake, Ohio, United States

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Eugene, Oregon, United States

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Clairton, Pennsylvania, United States

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Webster, Texas, United States

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Everett, Washington, United States

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Monroe, Washington, United States

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Seattle, Washington, United States

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Milwaukee, Wisconsin, United States

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Port Macquarie, New South Wales, Australia

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Wahroong, New South Wales, Australia

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Westmead, New South Wales, Australia

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Wodonga, Victoria, Australia

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Brussels, , Belgium

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Liège, , Belgium

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Mons, , Belgium

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Namur, , Belgium

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Wilrijk, , Belgium

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Salvador, Estado de Bahia, Brazil

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Belo Horizonte, Minas Gerais, Brazil

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Rio de Janeiro, Rio de Janeiro, Brazil

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Caxias do Sul, Rio Grande do Sul, Brazil

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Santo André, São Paulo, Brazil

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Sherbrooke, Quebec, Canada

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Wuhan, Hubei, China

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Ústí nad Labem, , Czechia

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Herlev, , Denmark

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Koebenhavn Oe, , Denmark

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Odense C, , Denmark

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Tampere, , Finland

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Saint-Grégoire, , France

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Tours, , France

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Berlin, , Germany

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Homburg/Saar, , Germany

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Kempen, , Germany

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Leipzig, , Germany

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München, , Germany

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Münster, , Germany

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Tübingen, , Germany

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Ulm, , Germany

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Kfar Saba, , Israel

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Petah Tikva, , Israel

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Tel Litwinsky, , Israel

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Ẕerifin, , Israel

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Meldola, FC, Italy

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Lido Di Camaiore (LU), , Italy

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Arequipa, Arequipa, Peru

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Martin, , Slovakia

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Žilina, , Slovakia

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Goyang-si, Gyeonggi-do, South Korea

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Seongnam, Gyunggido, South Korea

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Seoul, , South Korea

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Seoul, , South Korea

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A Coruña, A Coruña, Spain

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Elche, Alicante, Spain

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Barcelona, Barcelona, Spain

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L'Hospitalet de Llobregat, Barcelona, Spain

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Guadalajara, Guadalajara, Spain

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Pamplona, Navarre, Spain

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Seville, Sevilla, Spain

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Valencia, Valencia, Spain

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Lund, , Sweden

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Malmo, , Sweden

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Stockholm, , Sweden

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Vaxjo, , Sweden

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Taichung, , Taiwan

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Taipei, , Taiwan

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Taipei, , Taiwan

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Taoyuan District, , Taiwan

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Bournemouth, Dorset, United Kingdom

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Preston, Lancashire, United Kingdom

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Northwood, Middlesex, United Kingdom

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Bristol, , United Kingdom

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Cardiff, , United Kingdom

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Glasgow, , United Kingdom

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Guildford, , United Kingdom

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London, , United Kingdom

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Sheffield, , United Kingdom

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Swansea, , United Kingdom

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Countries

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United States Australia Belgium Brazil Canada China Czechia Denmark Finland France Germany Israel Italy Peru Poland Portugal Slovakia South Korea Spain Sweden Taiwan United Kingdom

References

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Michaelson MD, Oudard S, Ou YC, Sengelov L, Saad F, Houede N, Ostler P, Stenzl A, Daugaard G, Jones R, Laestadius F, Ullen A, Bahl A, Castellano D, Gschwend J, Maurina T, Chow Maneval E, Wang SL, Lechuga MJ, Paolini J, Chen I. Randomized, placebo-controlled, phase III trial of sunitinib plus prednisone versus prednisone alone in progressive, metastatic, castration-resistant prostate cancer. J Clin Oncol. 2014 Jan 10;32(2):76-82. doi: 10.1200/JCO.2012.48.5268. Epub 2013 Dec 9.

Reference Type DERIVED
PMID: 24323035 (View on PubMed)

Related Links

Other Identifiers

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A6181120

Identifier Type: -

Identifier Source: org_study_id

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