Impact on Reducing the Incidence of Low Serum Calcium by Providing Educational Materials on the Need to Take Daily Supplemental Calcium and Vitamin D to Patients With Paget's Disease Treated With Reclast®

NCT ID: NCT00668200

Last Updated: 2015-03-06

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

81 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-05-31

Study Completion Date

2012-11-30

Brief Summary

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This study will evaluate the impact of investigator and patient education and educational materials to foster calcium and vitamin D supplementation to mitigate the potential for hypocalcemia post Reclast® administration in patients with Paget's disease of bone.

Detailed Description

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Conditions

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Paget's Disease of the Bone Hypocalcemia

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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zoledronic acid

5 mg of Reclast (ZOL446, zoledronic acid) injection in 100 mL ready to infuse solution administered intravenously via a vented line. The infusion time was to be not less than 15 minutes given over a constant infusion rate.

Group Type OTHER

Reclast (ZOL446, zoledronic acid)

Intervention Type DRUG

5 mg i.v. annually ("real-life, physician prescribed")

Calcium

Intervention Type DIETARY_SUPPLEMENT

1500 mg elemental calcium daily in divided doses (the divided doses were 2-3 times per day depending on the formulation)

Vitamin D

Intervention Type DIETARY_SUPPLEMENT

800 IU vitamin D daily, particularly in the immediate 2 weeks following zoledronic acid administration

Interventions

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Reclast (ZOL446, zoledronic acid)

5 mg i.v. annually ("real-life, physician prescribed")

Intervention Type DRUG

Calcium

1500 mg elemental calcium daily in divided doses (the divided doses were 2-3 times per day depending on the formulation)

Intervention Type DIETARY_SUPPLEMENT

Vitamin D

800 IU vitamin D daily, particularly in the immediate 2 weeks following zoledronic acid administration

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Reclast, ZOL446

Eligibility Criteria

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Inclusion Criteria

* Written informed consent
* As per currently approved Reclast® Package Insert:

Exclusion Criteria

\- As per currently approved Reclast® Package Insert:
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novartis Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Novartis Pharmaceuticals

Role: STUDY_DIRECTOR

Novartis Pharmaceuticals

Locations

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Novartis Investigative Site

Phoenix, Arizona, United States

Site Status

Novartis Investigative Site

Tucson, Arizona, United States

Site Status

Novartis Investigative Site

Gainesville, Georgia, United States

Site Status

Novartis Investigative Site

Detroit, Michigan, United States

Site Status

Novartis Investigative Site

Syracuse, New York, United States

Site Status

Novartis Investigative Site

Providence, Rhode Island, United States

Site Status

Novartis Investigative Site

Dallas, Texas, United States

Site Status

Novartis Investigative Site

Waco, Texas, United States

Site Status

Novartis Investigative Site

Madison, Wisconsin, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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CZOL446K2401

Identifier Type: -

Identifier Source: org_study_id

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