Assess Efficacy in Subjects With Traumatic Spinal Cord Injury

NCT ID: NCT00667966

Last Updated: 2015-05-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-07-31

Study Completion Date

2007-02-28

Brief Summary

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Assess efficacy of Vardenafil in patients with traumatic spinal cord injury

Detailed Description

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Conditions

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Erectile Dysfunction Spinal Cord Injury

Keywords

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Spinal cord injury Urodynamic Erectile dysfunction Vardenafil

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Vardenafil + Placebo

Subjects received single dose of 10 mg vardenafil followed by 20 mg vardenafil and then crossed over to 10 mg placebo followed by 20 mg placebo.

Group Type EXPERIMENTAL

Vardenafil (Levitra, BAY 38-9456), 10 mg

Intervention Type DRUG

10 mg vardenafil was administered with a glass of water 1 h before starting the test with the stimulator.

Placebo

Intervention Type DRUG

10/20 mg placebo in sequence in respective arm

Vardenafil (Levitra, BAY 38-9456), 20 mg

Intervention Type DRUG

20 mg vardenafil was administered with a glass of water 1 h before starting the test with the stimulator.

Placebo + Vardenafil

Subjects received single dose of 10 mg placebo followed by 20 mg placebo and then crossed over to 10 mg vardenafil followed by 20 mg vardenafil.

Group Type EXPERIMENTAL

Vardenafil (Levitra, BAY 38-9456), 10 mg

Intervention Type DRUG

10 mg vardenafil was administered with a glass of water 1 h before starting the test with the stimulator.

Placebo

Intervention Type DRUG

10/20 mg placebo in sequence in respective arm

Vardenafil (Levitra, BAY 38-9456), 20 mg

Intervention Type DRUG

20 mg vardenafil was administered with a glass of water 1 h before starting the test with the stimulator.

Interventions

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Vardenafil (Levitra, BAY 38-9456), 10 mg

10 mg vardenafil was administered with a glass of water 1 h before starting the test with the stimulator.

Intervention Type DRUG

Placebo

10/20 mg placebo in sequence in respective arm

Intervention Type DRUG

Vardenafil (Levitra, BAY 38-9456), 20 mg

20 mg vardenafil was administered with a glass of water 1 h before starting the test with the stimulator.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Men between 18 and 64 years old with stable cord injury (more than 6 months) who had erectile dysfunction according to the National Institutes if Health (NIH) after their traumatic spinal cord injury

Exclusion Criteria

* Primary hypoactive sexual desire
* History of myocardial infarction, stroke or life-threatening arrhythmia within prior 6 month
* Nitrate therapy
Minimum Eligible Age

18 Years

Maximum Eligible Age

64 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Bayer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bayer Study Director

Role: STUDY_DIRECTOR

Bayer

Locations

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Badalona, Barcelona, Spain

Site Status

Toledo, Toledo, Spain

Site Status

Countries

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Spain

Related Links

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http://www.clinicaltrialsregister.eu/

Click here to find information about studies related to Bayer Healthcare products conducted in Europe

Other Identifiers

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2004-005282-37

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

11861

Identifier Type: -

Identifier Source: org_study_id