Paclitaxel and Bortezomib in Treating Patients With Metastatic or Unresectable Malignant Solid Tumors

NCT ID: NCT00667641

Last Updated: 2011-05-10

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 16 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2007-03-31
• Study Completion Date: 2009-02-28

Brief Summary

RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving paclitaxel together with bortezomib may kill more tumor cells.

PURPOSE: This phase I trial is studying the side effects and best dose of paclitaxel and bortezomib in treating patients with metastatic or unresectable malignant solid tumors.

Detailed Description

OBJECTIVES:

Primary

• To identify the maximum tolerated dose of paclitaxel in combination with bortezomib in patients with metastatic or unresectable solid tumor malignancies that involve an activated Ras/Raf/MAPK pathway.

Secondary

• To assess the toxicity of this regimen.
• To assess tumor response in these patients.
• To determine whether Bim is upregulated in peripheral blood mononuclear cells obtained from patients treated with this regimen.
• To correlate markers of Ras/Raf/MAPK pathway activation in fresh or archived tumor tissue with clinical response in these patients.
• To perform pharmacokinetic (PK) studies to determine whether bortezomib alters paclitaxel PK parameters.

OUTLINE: Patients receive paclitaxel IV over 1 hour and bortezomib IV on days 1, 8, and 15. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity.

Blood samples are collected at baseline and periodically during course 1 for pharmacokinetic and biomarker studies. Blood samples are analyzed for plasma concentrations of paclitaxel by high performance liquid chromatography and for Bim protein levels and phosphorylation status by western blotting. Tumor tissue samples, if available, are analyzed to evaluate the presence of an activated Ras/Raf/MAPK pathway. Tumor tissue samples are analyzed for Ras and/or Raf mutations by nucleic acid extraction and direct sequencing; Ras and/or Raf overexpression by western blotting; Ras activation assay; and/or phospho-ERK by western blotting and IHC.

Conditions

Breast Cancer; Colorectal Cancer; Head and Neck Cancer; Lung Cancer; Melanoma (Skin); Ovarian Cancer; Pancreatic Cancer; Prostate Cancer; Unspecified Adult Solid Tumor, Protocol Specific

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Interventions

bortezomib

Starting dose level 0.70mg/m2

Intervention Type: DRUG

paclitaxel

Starting dose level 40mg/m2

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed malignant solid tumor that involves an activated Ras/Raf/MAPK pathway, including the following:

• Breast cancer
• Prostate cancer
• Colon cancer
• Pancreatic cancer
• Ovarian cancer
• Non-small cell lung cancer
• Melanoma
• Papillary thyroid cancer
• Metastatic or unresectable disease
• Standard curative or palliative measures do not exist or are no longer effective
• No newly diagnosed, untreated, or uncontrolled brain metastases

PATIENT CHARACTERISTICS:

• ECOG performance status 0-2
• ANC ≥ 1,500/μL
• WBC ≥ 3,500/μL
• Platelet count ≥ 100,000/μL
• Total bilirubin ≤ 1.5 times upper limit of normal (ULN)
• AST/ALT ≤ 2.5 times ULN (≤ 5 times ULN for tumor involvement of the liver)
• Creatinine ≤ 2 times ULN
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No neuropathy ≥ grade 1 with pain within the past 14 days
• No active infections
• No myocardial infarction within the past 6 months
• No NYHA class III or IV heart failure
• No uncontrolled angina
• No severe uncontrolled ventricular arrhythmias
• No evidence of acute ischemia or active conduction system abnormalities by ECG

• Any ECG abnormality at screening must be documented by the investigator as not medically relevant
• No hypersensitivity to bortezomib, boron, or mannitol
• No serious medical or psychiatric illness likely to interfere with study participation

PRIOR CONCURRENT THERAPY:

• Prior paclitaxel or bortezomib allowed
• At least 4 weeks since prior chemotherapy and/or radiotherapy
• More than 14 days since other prior investigational drugs
• No other concurrent investigational agents
• No other concurrent anticancer agents, including chemotherapy and biologic agents
• No concurrent recombinant interleukin-11 (Neumega®)

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Cancer Institute (NCI)

NIH

Sponsor Role: collaborator

University of Medicine and Dentistry of New Jersey

OTHER

Sponsor Role: lead

Responsible Party

UMDNJ/CINJ

Principal Investigators

Vassil Karantza-Wadsworth, MD

Role: PRINCIPAL_INVESTIGATOR

Rutgers Cancer Institute of New Jersey

Locations

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School

New Brunswick, New Jersey, United States

Countries

United States

Related Links

http://www.clinicaltrials.gov/ct2/show/NCT00667641

Clinical trial summary from the National Cancer Institute's PDQ® database

Other Identifiers

P30CA072720

Identifier Type: NIH

Identifier Source: secondary_id

View Link

CINJ-050608

Identifier Type: -

Identifier Source: secondary_id

MILLENNIUM-CINJ-050608

Identifier Type: -

Identifier Source: secondary_id

CINJ-IRB-0220060270

Identifier Type: -

Identifier Source: secondary_id

CDR0000592905

Identifier Type: -

Identifier Source: org_study_id