Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises

NCT ID: NCT00660465

Last Updated: 2014-11-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

6 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-05-31

Brief Summary

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The purpose of this study is to explore how arterial PaCO2 effect regional Blood Oxygen Level Dependent (BOLD) signal, and indirectly the brain regional O2 level .

Detailed Description

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Among many parameters effecting cerebral blood flow(CBF), partial pressure of CO2 (PaCO2) in arterial blood has a significant effect. A small increase in arterial PaCO2 level will cause a significant increase of CBF , followed by increase of O2 level . The main objective is to explore the effect of arterial PaCO2 level on regional CBF and brain O2 level, by using breathing exercises to modulate arterial PaCO2. The regional Blood Oxygen Level Dependent (BOLD) signal produced by MRI , will indicate the regional O2 level.

Conditions

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Healthy

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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A18

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* adults over 18 years old .

Exclusion Criteria

* under 18 years old.
* Artificial pacemaker
* implantable cardioverter-defibrillator (ICD)
* Hearing aid, implantable or portable.
* artificial heart valve
* Surgical clips
* Metal fragments in eyes
* Electronic stimulators
* Implanted pumps
* Implantable Neurostimulation Device
* metal fragments of any sort
* Permanent makeup or tattoo
* transfusion pump
* pregnant or breast feeding women
* False teeth , retainer or dental crown
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Soroka University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Ben-Gurion University of the Negev

Principal Investigators

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Ilan Shelef, M.D

Role: STUDY_DIRECTOR

Head, Neuroradiolgy Unit ;Department of Diagnostic Imaging ;Soroka Univrsity Medical Center

Locations

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Department of Diagnostic Imaging ;Soroka Univrsity Medical Center

Beersheba, , Israel

Site Status

Countries

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Israel

Central Contacts

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Alexander Gersten, Ph.D

Role: CONTACT

+972-52-3906012

Facility Contacts

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Ilan Shelef, M.D

Role: primary

+972-8-6403950

Other Identifiers

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SOR467608CTIL

Identifier Type: -

Identifier Source: org_study_id