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Comparison of Acceleromyography (AMG) and Mechanomyography (MMG) for Establishing Potency of Neuromuscular Blocking Agents

NCT ID: NCT00660413

Last Updated: 2008-04-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-12-31

Study Completion Date

2008-02-29

Brief Summary

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The purpose of this study was to compare two methods for neuromuscular monitoring, acceleromyography and mechanomyography for establishing the dose-response relationship and the potency of a neuromuscular blocking agent using rocuronium as an example. We hypothesized that there would be no significant difference between potencies estimated using acceleromyography and mechanomyography.

Detailed Description

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Conditions

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Neuromuscular Blockade

Keywords

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Acceleromyography Mechanomyography Neuromuscular block Neuromuscular monitoring Dose-response Potency Rocuronium

Study Design

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Allocation Method

RANDOMIZED

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Study Groups

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AMG

Acceleromygraphy monitoring

Group Type EXPERIMENTAL

TOF-Watch SX (Acceleromyography)

Intervention Type DEVICE

Randomization of AMG to dominant or non-dominant arm. MMG at contralateral arm.

MMG

Mechanomyography monitoring

Group Type ACTIVE_COMPARATOR

TOF-Watch SX (Acceleromyography)

Intervention Type DEVICE

Randomization of AMG to dominant or non-dominant arm. MMG at contralateral arm.

Interventions

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TOF-Watch SX (Acceleromyography)

Randomization of AMG to dominant or non-dominant arm. MMG at contralateral arm.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* ASA I-III
* Ideal weight +/-20%
* Both arms available for neuromuscular monitoring
* Surgery in supine position
* Participated surgery time more than 30 min

Exclusion Criteria

* Pregnant and breast-feeding women
* Patients with known illness or use of medications known to influence the neuromuscular transmission
* Known significant renal or hepatic dysfunction
* Allergy to medications used in the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rigshospitalet, Denmark

OTHER

Sponsor Role lead

Principal Investigators

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Casper Claudius, MD

Role: PRINCIPAL_INVESTIGATOR

Rigshospitalet, Denmark

Locations

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Rigshospitalet

Copenhagen, Østerbro, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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AMG-MMG D-R

Identifier Type: -

Identifier Source: org_study_id