Metabolic Effects of Enfuvirtide in Healthy Volunteers

NCT ID: NCT00657761

Last Updated: 2008-04-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-09-30

Study Completion Date

2006-03-31

Brief Summary

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The metabolic effects of T-20 are not completely known, since the drug is used in combination with other antiretroviral agents. A short-term study in healthy volunteers, with a double-blind crossover design vs. placebo will illustrate if there may be some direct metabolic effects without the influence of HIV infection and the concurrent use of other drugs.

Detailed Description

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Conditions

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HIV Infections

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo

Saline solution 0.9% sc/12h for 7 days

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

0.9% saline solution/12h sc for 7 days

Enfuvirtide

Enfuvirtide 90 mg/12h sc for 7 days

Group Type EXPERIMENTAL

Enfuvirtide

Intervention Type DRUG

90 mg/12h sc for 7 days

Interventions

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Enfuvirtide

90 mg/12h sc for 7 days

Intervention Type DRUG

Placebo

0.9% saline solution/12h sc for 7 days

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy adult males
* BMI between 19-24.9 kg/m2
* No active concomitant clinical conditions
* Negative HIV, HBV and HCV serologies
* Negative abuse drug urine test

Exclusion Criteria

* Prior psychiatric illness
* Prior dyslipemia
* Alcohol consumption \> 30g/day
* Caffeine consumption \> 5 units/day
* Current smoker
* Known drug allergies
* Participation in other drug trials in the previous 3 months
* No medications in the previous 30 days
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role collaborator

Hospital Clinic of Barcelona

OTHER

Sponsor Role lead

Responsible Party

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Hospital Clinic, Barcelona

Principal Investigators

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Neus Riba, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital Clinic of Barcelona

Locations

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Hospital Clinic

Barcelona, Barcelona, Spain

Site Status

Countries

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Spain

Other Identifiers

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EudraCT #: 2005-002018-39

Identifier Type: -

Identifier Source: secondary_id

ENF/01FD-05/UF1

Identifier Type: -

Identifier Source: org_study_id