Prophylaxis In Venous Thromboembolism In Primary Care, A Pilot Study

NCT ID: NCT00655122

Last Updated: 2008-09-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE4

Total Enrollment

8 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-04-30

Study Completion Date

2003-12-31

Brief Summary

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The primary objective was to study the clinical benefit with dalteparin sodium in thromboprophylaxis in primary care medical subjects. The secondary objective was a pharmacoeconomic evaluation of hromboprophylaxis with dalteparin sodium in primary care medical subjects.

Detailed Description

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The study was prematurely terminated on December 9, 2003. The reason for the early termination was not related to a safety or efficacy issue. It was related to the difficulty in recruiting patients.

Conditions

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Thromboembolism Deep Vein Thrombosis Dalteparin

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Dalteparin sodium

Group Type ACTIVE_COMPARATOR

Dalteparin sodium

Intervention Type DRUG

Dalteparin sodium was administered at a daily dosage of 5,000 UI anti-Xa by subcutaneous route. The treatment duration was 7 days in a single daily injection throughout the bedridden period.

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo was administered with a daily injection of 0.2 mL by subcutaneous route. The treatment duration was 7 days in a single daily injection throughout the bedridden period.

Interventions

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Dalteparin sodium

Dalteparin sodium was administered at a daily dosage of 5,000 UI anti-Xa by subcutaneous route. The treatment duration was 7 days in a single daily injection throughout the bedridden period.

Intervention Type DRUG

Placebo

Placebo was administered with a daily injection of 0.2 mL by subcutaneous route. The treatment duration was 7 days in a single daily injection throughout the bedridden period.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age \> 65 years
* Confinement to bed for more than 3 days, due to:
* Heart failure
* Exacerbated chronic obstructive pulmonary disease
* Acute rheumatic involvement
* Written informed consent

Exclusion Criteria

1. Cancer
2. Anticoagulant treatment in the previous 3 months
3. Stroke or major surgery in the previous 3 months
4. Systolic pressure \>200 mmHg or diastolic pressure \>120 mmHg
5. Known chronic hepatopathy
6. Active hemorrhage in any site in the previous 3 months
7. Active peptic ulcer
8. Bacterial endocarditis
9. Conditions that can increase the risk of hemorrhage
10. Known coagulation disorders
11. Hypersensitivity to heparin or HIT
12. Life expectancy of less than 3 months
13. Previous confinement to bed during more than 3 days
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Pfizer, Inc.

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

León, , Spain

Site Status

Pfizer Investigational Site

Madrid, , Spain

Site Status

Pfizer Investigational Site

Madrid, , Spain

Site Status

Pfizer Investigational Site

Parla, , Spain

Site Status

Pfizer Investigational Site

Torremolinos, , Spain

Site Status

Countries

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Spain

Related Links

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Other Identifiers

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A6301036

Identifier Type: -

Identifier Source: secondary_id

FGMAEI-0042-046

Identifier Type: -

Identifier Source: org_study_id