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Mitral Valve Area Assessment: Comparison With Transthoracic Echocardiography and Magnetic Resonance Imaging

NCT ID: NCT00654472

Last Updated: 2008-04-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-04-30

Study Completion Date

2008-06-30

Brief Summary

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To compare mitral valve area in rheumatic mitral valve stenosis with cardiac magnetic resonance imaging and conventional transthoracic echocardiography.

Detailed Description

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Clinical assessment of severity of mitral stenosis depends on both the presence of symptoms and mitral valve area . Evaluation of mitral valve area with transthoracic echocardiography maintains rapid, accurate analysis of valve disease and serves as a practical gold standard for clinical evaluation. Cardiac magnetic resonance imaging (CMRI) is a recently used method that allows to evaluate cardiac structures and function noninvasively. Direct visualization of valve area with CMRI is also possible and it has been shown that the valve area assessed by CMRI planimetry correlates reliably with the invasive assessment. Velocity-encoded cardiac magnetic resonance imaging can be used to quantify mitral valve area. The objective of this study was to evaluate mitral valve area with CMRI and compare it with echocardiographic methods including 2D planimetry, Doppler continuation equation and Doppler pressure half-time

Conditions

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Mitral Valve Stenosis

Keywords

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magnetic resonance imaging, mitral valve area

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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A

Mitral valve area above 1.5 cm2

No interventions assigned to this group

B

Mitral valve area 1.5 cm2 and below 1.5 cm2

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* rheumatic mitral valve stenosis

Exclusion Criteria

* Degenerative mitral valve disease
* EF\<50%
* atrial fibrillation
* inconclusive planimetric assessment
* moderate or severe mitral regurgitation
* moderate or severe aortic regurgitation
* history of previous mitral valve commissurotomy or balloon valvotomy
Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Florence Nightingale Hospital, Istanbul

OTHER

Sponsor Role lead

Responsible Party

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T.C. Istanbul Bilim University, Florence Nightingale Hospital

Principal Investigators

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Saide Aytekin, Professor

Role: STUDY_DIRECTOR

T.C. Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology

Locations

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Florence Nightinngale Hospital

Istanbul, , Turkey (Türkiye)

Site Status RECRUITING

TC.Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology

Istanbul, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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Saide Aytekin, Professor

Role: CONTACT

Phone: 00902122244950

Email: [email protected]

Özlem Yıldırımtürk, Professor

Role: CONTACT

Phone: 00902122244950

Email: [email protected]

Facility Contacts

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Saide Ayetkin, Professor

Role: primary

Özlem Yıldırımtürk, MD

Role: backup

Saide Aytekin, Professor

Role: primary

References

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Lin SJ, Brown PA, Watkins MP, Williams TA, Lehr KA, Liu W, Lanza GM, Wickline SA, Caruthers SD. Quantification of stenotic mitral valve area with magnetic resonance imaging and comparison with Doppler ultrasound. J Am Coll Cardiol. 2004 Jul 7;44(1):133-7. doi: 10.1016/j.jacc.2004.03.038.

Reference Type BACKGROUND
PMID: 15234421 (View on PubMed)

Djavidani B, Debl K, Lenhart M, Seitz J, Paetzel C, Schmid FX, Nitz WR, Feuerbach S, Riegger G, Luchner A. Planimetry of mitral valve stenosis by magnetic resonance imaging. J Am Coll Cardiol. 2005 Jun 21;45(12):2048-53. doi: 10.1016/j.jacc.2005.03.036.

Reference Type BACKGROUND
PMID: 15963408 (View on PubMed)

Other Identifiers

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OY1975

Identifier Type: -

Identifier Source: org_study_id