A Dose-Ranging Study Of Valdecoxib 5 Mg, 10 Mg, And 20 Mg Once Daily Versus Placebo In Patients With Osteoarthritis Of The Knee (Japan)

NCT ID: NCT00650624

Last Updated: 2018-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

416 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-06-30

Study Completion Date

2004-01-31

Brief Summary

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To determine the therapeutic dose range of valdecoxib by comparing the efficacy of three dosing regimens (5 mg, 10 mg and 20 mg once daily) with placebo for relief of the signs and symptoms of osteoarthritis of the knee. To assess safety and tolerability of multiple doses of valdecoxib in patients with osteoarthritis of the knee.

Detailed Description

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Conditions

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Osteoarthritis, Knee

Keywords

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knee osteoarthritis; Japan

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Arm 1

Group Type ACTIVE_COMPARATOR

valdecoxib

Intervention Type DRUG

valdecoxib 5 mg tablet by mouth once daily in the morning for 6 weeks

Arm 2

Group Type ACTIVE_COMPARATOR

valdecoxib

Intervention Type DRUG

valdecoxib 10 mg tablet by mouth once daily in the morning for 6 weeks

Arm 3

Group Type ACTIVE_COMPARATOR

valdecoxib

Intervention Type DRUG

valdecoxib 20 mg tablet by mouth once daily in the morning for 6 weeks

Arm 4

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

placebo tablet by mouth once daily in the morning for 6 weeks

Interventions

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valdecoxib

valdecoxib 5 mg tablet by mouth once daily in the morning for 6 weeks

Intervention Type DRUG

valdecoxib

valdecoxib 10 mg tablet by mouth once daily in the morning for 6 weeks

Intervention Type DRUG

valdecoxib

valdecoxib 20 mg tablet by mouth once daily in the morning for 6 weeks

Intervention Type DRUG

placebo

placebo tablet by mouth once daily in the morning for 6 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed with symptomatic OA of the knee by the American College of Rheumatology (ACR) criteria and a Functional Capacity Classification (FCC) of I - III at Screening Visit and were walking
* At the Baseline visit, eligible patients were to have Patient's Assessment of Arthritis Pain VAS ≥ 40 mm and Patient's \& Physician's Global Assessment of Arthritis of "Poor" or "Very Poor"

Exclusion Criteria

* Patients unable to walk generally
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Pfizer, Inc.

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Funabashi, Chiba, Japan

Site Status

Pfizer Investigational Site

Sakura, Chiba, Japan

Site Status

Pfizer Investigational Site

Chikushi-gun, Fukuoka, Japan

Site Status

Pfizer Investigational Site

Iizuka, Fukuoka, Japan

Site Status

Pfizer Investigational Site

Kurume, Fukuoka, Japan

Site Status

Pfizer Investigational Site

Yame, Fukuoka, Japan

Site Status

Pfizer Investigational Site

Chitose, Hokkaido, Japan

Site Status

Pfizer Investigational Site

Sapporo, Hokkaido, Japan

Site Status

Pfizer Investigational Site

Kamakura, Kanagawa, Japan

Site Status

Pfizer Investigational Site

Yokohama, Kanagawa, Japan

Site Status

Pfizer Investigational Site

Isahaya, Nagasaki, Japan

Site Status

Pfizer Investigational Site

Hirakata, Osaka, Japan

Site Status

Pfizer Investigational Site

Kanzaki-gun, Saga-ken, Japan

Site Status

Pfizer Investigational Site

Karatsu, Saga-ken, Japan

Site Status

Pfizer Investigational Site

Ogi-gun, Saga-ken, Japan

Site Status

Pfizer Investigational Site

Itabashi-ku, Tokyo, Japan

Site Status

Pfizer Investigational Site

Setagaya-ku, Tokyo, Japan

Site Status

Pfizer Investigational Site

Shinjuku-Ku, Tokyo, Japan

Site Status

Pfizer Investigational Site

Taito-ku, Tokyo, Japan

Site Status

Pfizer Investigational Site

Yoyogi Shibuya-ku, Tokyo, Japan

Site Status

Pfizer Investigational Site

Saga, , Japan

Site Status

Pfizer Investigational Site

Tokyo, , Japan

Site Status

Countries

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Japan

Related Links

Other Identifiers

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A3471090

Identifier Type: -

Identifier Source: secondary_id

VALAJP-8274-156

Identifier Type: -

Identifier Source: org_study_id