A Study to Evaluate the Safety of Adjuvant Treatment With Exemestane Following Previous Treatment With Tamoxifen in Postmenopausal Women With Estrogen Sensitive Primary Breast Cancer

NCT ID: NCT00649090

Last Updated: 2008-09-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

1549 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-03-31

Study Completion Date

2007-04-30

Brief Summary

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The purpose of this study was to give access to postmenopausal women with estrogen sensitive primary breast cancer to exemestane for the adjuvant treatment of breast cancer after the use of tamoxifen and to collect all serious adverse events.

Detailed Description

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Conditions

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Breast Neoplasms

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Exemestane group

Group Type ACTIVE_COMPARATOR

exemestane

Intervention Type DRUG

Exemestane 25 mg oral tablet once daily for a maximum of 3 years

Interventions

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exemestane

Exemestane 25 mg oral tablet once daily for a maximum of 3 years

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Postmenopausal patients
* Patients with early breast cancer after adequate loco-regional treatment and eventual adjuvant chemotherapy, treated with tamoxifen for 2-3 years OR treated with tamoxifen for 2-3 years and consecutive exemestane treatment, provided the total duration of endocrine treatment is less than 5 years
* Estrogen receptor positive breast cancer patients
* Patients who remain free from disease following treatment with tamoxifen

Exclusion Criteria

* Patients taking other drugs for the adjuvant treatment of breast cancer
* Patients taking hormone replacement therapy
* Donation of blood or blood products for transfusion during the 30 days prior to initiation of treatment with study drug, at any time during the program or 30 days after completion of treatment
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Pfizer, Inc.

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Aalst, , Belgium

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Antwerp, , Belgium

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Arlon, , Belgium

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Baudour, , Belgium

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Bonheiden, , Belgium

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Bouge, , Belgium

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Boussu, , Belgium

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Braine-l'Alleud, , Belgium

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Brasschaat, , Belgium

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Bruges, , Belgium

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Brussels, , Belgium

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Brussels, , Belgium

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Brussels, , Belgium

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Brussels, , Belgium

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Brussels, , Belgium

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Brussels, , Belgium

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Brussels, , Belgium

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Brussels, , Belgium

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Brussels, , Belgium

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Charleroi, , Belgium

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Chênée, , Belgium

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Chimay, , Belgium

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Dendermonde, , Belgium

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Duffel, , Belgium

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Edegem, , Belgium

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Eupen, , Belgium

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Genk, , Belgium

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Ghent, , Belgium

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Gilly (Charleroi), , Belgium

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Gosselies, , Belgium

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Halle, , Belgium

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Hasselt, , Belgium

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Herstal, , Belgium

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Hornu, , Belgium

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Huy, , Belgium

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Kortrijk, , Belgium

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La Louvière, , Belgium

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Leuven, , Belgium

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Libramont, , Belgium

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Lier, , Belgium

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Liège, , Belgium

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Mechelen, , Belgium

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Merksem, , Belgium

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Mons, , Belgium

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Montigny-le-Tilleul, , Belgium

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Mouscron, , Belgium

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Namur, , Belgium

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Ottignies, , Belgium

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Rocourt, , Belgium

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Roeselare, , Belgium

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Seraing, , Belgium

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Sint-Niklaas, , Belgium

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Soignies, , Belgium

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Tongeren, , Belgium

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Torhout, , Belgium

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Tournai, , Belgium

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Turnhout, , Belgium

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Verviers, , Belgium

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Waregem, , Belgium

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Wilrijk, , Belgium

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Yvoir, , Belgium

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Countries

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Belgium

Related Links

Other Identifiers

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A5991077

Identifier Type: -

Identifier Source: org_study_id