Very Low Density Lipoprotein (VLDL) Triglyceride Metabolism in Exercise

NCT ID: NCT00647452

Last Updated: 2011-11-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-04-30

Study Completion Date

2009-04-30

Brief Summary

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Purpose:

To investigate VLDL-TG metabolism in exercise in healthy volunteers to determine the contribution of VLDL-TG in exercise and eventual gender differences

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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1

Healthy male volunteers

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

Moderate Intensity Exercise (50 % af VO2max) for 90 minutes

2

Healthy female volunteers

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

Moderate Intensity Exercise (50 % af VO2max) for 90 minutes

Interventions

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Exercise

Moderate Intensity Exercise (50 % af VO2max) for 90 minutes

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Healthy
* Age: 20-50 years
* Premenopausal

Exclusion Criteria

* Smoking
* Alcohol abuse
* Use of medications
Minimum Eligible Age

20 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Esben Søndergaard, M.D.

Role: PRINCIPAL_INVESTIGATOR

Medical Department M

Locations

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Department of Endocrinology M, Aarhus Hospital

Aarhus C, , Denmark

Site Status

Countries

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Denmark

References

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Mittendorfer B, Horowitz JF, Klein S. Effect of gender on lipid kinetics during endurance exercise of moderate intensity in untrained subjects. Am J Physiol Endocrinol Metab. 2002 Jul;283(1):E58-65. doi: 10.1152/ajpendo.00504.2001.

Reference Type BACKGROUND
PMID: 12067843 (View on PubMed)

Gormsen LC, Jensen MD, Nielsen S. Measuring VLDL-triglyceride turnover in humans using ex vivo-prepared VLDL tracer. J Lipid Res. 2006 Jan;47(1):99-106. doi: 10.1194/jlr.M500205-JLR200. Epub 2005 Oct 18.

Reference Type BACKGROUND
PMID: 16234572 (View on PubMed)

Other Identifiers

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ES-0002

Identifier Type: -

Identifier Source: org_study_id