Safety and Efficacy Study of Cefdinir Oral Suspension, in Pediatric Subjects to Treat Acute Otitis Media

NCT ID: NCT00645203

Last Updated: 2008-03-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

447 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-07-31

Brief Summary

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To evaluate the safety and efficacy of cefdinir oral suspension in children between 6 months and 4 years of age, with acute otitis media, who are at risk of persistent or recurrent otitis media.

Detailed Description

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Conditions

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Acute Otitis Media

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type OTHER

cefdinir

Intervention Type DRUG

cefdinir oral suspension, 25 mg/kg once daily for 10 days

Interventions

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cefdinir

cefdinir oral suspension, 25 mg/kg once daily for 10 days

Intervention Type DRUG

Other Intervention Names

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ABT-198, Omnicef, cefdinir

Eligibility Criteria

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Inclusion Criteria

* Male and female children between 6 months and 4 years of age
* Weight does not exceed 40 kg
* Clinical diagnosis is acute otitis media
* Have evidence of middle ear fluid
* At risk for persistent or recurrent otitis media
* Generally in good health

Exclusion Criteria

* Sensitivity or allergy to penicillins or cephalosporins or inability to take oral medications
* Presence of tympanostomy tubes, ventilation tube or perforated tympanic membrane, in either ear
* Treatment with any anti-infective agent within 3 days prior to the study or treatment with a long-acting injectable antimicrobial agent (e.g. , penicillin G benzathine) within 4 weeks prior to the study
* Concomitant infection, that requires additional antimicrobial therapy
* Presence of a disease, complicating factor (e.g., mastoiditis), or structural abnormality that would preclude evaluation of the patient's therapeutic response
Minimum Eligible Age

6 Months

Maximum Eligible Age

4 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott

INDUSTRY

Sponsor Role lead

Responsible Party

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Abbott

Locations

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Scottsdale, Arizona, United States

Site Status

Clovis, California, United States

Site Status

Dinuba, California, United States

Site Status

Folsom, California, United States

Site Status

Denver, Colorado, United States

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Brooklyn, New York, United States

Site Status

Rochester, New York, United States

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Rochester, New York, United States

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Chapel Hill, North Carolina, United States

Site Status

Erie, Pennsylvania, United States

Site Status

Pittsburgh, Pennsylvania, United States

Site Status

Dallas, Texas, United States

Site Status

Salt Lake City, Utah, United States

Site Status

Providencia, Santiago Metropolitan, Chile

Site Status

Puente Alto, Santiago, , Chile

Site Status

Uruca, Provincia de San José, Costa Rica

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San José, , Costa Rica

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Santo Domingo, , Dominican Republic

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Guatemala City, , Guatemala

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Guatemala City, , Guatemala

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Beersheba, , Israel

Site Status

Panama City, , Panama

Site Status

Countries

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United States Chile Costa Rica Dominican Republic Guatemala Israel Panama

Other Identifiers

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M01-352

Identifier Type: -

Identifier Source: org_study_id