Trial Outcomes & Findings for The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization (NCT NCT00644657)

Results Overview

The percentage of platelets that are collagen coated after the administration of clopidogrel.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

27 participants

Primary outcome timeframe

24 hours after the administration of clopidotrel

Results posted on

2011-10-07

Participant Flow

Patients scheduled for cardiac catheterization and possible percutaneous intervention who received a loading dose of 300 mg of clopidogrel were recruited.

Participant milestones

Participant milestones
Measure	Clopidogrel Loading Dose All subjects received a 300 mg loading dose of clopidogrel
Overall Study STARTED	27
Overall Study COMPLETED	27
Overall Study NOT COMPLETED	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Clopidogrel n=27 Participants All 27 subjects received a 300 mg loading dose of clopidogrel
Age Continuous	64 years STANDARD_DEVIATION 9 • n=5 Participants
Sex: Female, Male Female	2 Participants n=5 Participants
Sex: Female, Male Male	25 Participants n=5 Participants
The percentage of platelets that are "coated-Platelets" as measured by dual-agonist stimulation	40.0 percent coated platelets STANDARD_DEVIATION 14.3 • n=5 Participants

PRIMARY outcome

Timeframe: 24 hours after the administration of clopidotrel

The percentage of platelets that are collagen coated after the administration of clopidogrel.

Outcome measures

Outcome measures
Measure	Clopidogrel Loading Dose n=27 Participants All subjects received a 300 mg loading dose of clopidogrel
The Percentage of Coated Platelets After the Administration of Clopidogrel in Patients Undergoing Cardiac Catheterization and/or Angioplasty	32.8 Percent of platelets that are coated. Standard Deviation 13.6 • Interval 0.0 to 0.0

SECONDARY outcome

Timeframe: 6 hrs after procedure

The percentage of coated platelets 24 hours after coronary angiography and/or PCI

Outcome measures

Outcome measures
Measure	Clopidogrel Loading Dose n=27 Participants All subjects received a 300 mg loading dose of clopidogrel
The Percentage of Coated Platelets After Coronary Angiography and/or PCI	33.9 Percentage of platelets that are coated Standard Deviation 12.3

Adverse Events

Clopidogrel Loading Dose

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Eliot Schechter, MD

University of Oklahoma Health Sciences Center

Phone: 405-456-5378

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place