A Single, High-Dose Azithromycin Extended Release (60 mg/kg) Compared With 10 Days of High-Dose Amoxicillin Clavulanate in Children With Ear Infections at High Risk of Persistent/Recurrent Ear Infections

NCT ID: NCT00643292

Last Updated: 2011-05-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

902 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-01-31

Study Completion Date

2004-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

A phase 3 randomized, multicenter, double blind, double dummy study to assess the efficacy, safety, and compliance of a single dose of azithromycin extended release compared with a 10-day course of amoxicillin/clavulanate twice daily in children at high risk for persistent or recurrent ear infections

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Otitis Media

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Group Type EXPERIMENTAL

amoxicillin/clavulanate postassium (Augmentin ES-600)

Intervention Type DRUG

amoxicillin/clavulanate postassium 90/6.4 mg/kg/day, given in divided doses q12h, for 10 days

2

Group Type EXPERIMENTAL

azithromycin SR

Intervention Type DRUG

azithromycin SR 60 mg/kg x 1 dose

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

amoxicillin/clavulanate postassium (Augmentin ES-600)

amoxicillin/clavulanate postassium 90/6.4 mg/kg/day, given in divided doses q12h, for 10 days

Intervention Type DRUG

azithromycin SR

azithromycin SR 60 mg/kg x 1 dose

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Outpatients with clinical evidence of acute otitis media who weigh at least 5 kg were included

Exclusion Criteria

Patients with previously diagnosed disease of immune function, treatment with any systemic antibiotic within the previous 7 days, or cleft lip/palate or other anatomic abnormality predisposing to otitis media were excluded.
Minimum Eligible Age

3 Months

Maximum Eligible Age

48 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Pfizer, Inc.

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Pfizer Investigational Site

Jonesboro, Arkansas, United States

Site Status

Pfizer Investigational Site

Little Rock, Arkansas, United States

Site Status

Pfizer Investigational Site

Bellflower, California, United States

Site Status

Pfizer Investigational Site

Fountain Valley, California, United States

Site Status

Pfizer Investigational Site

Fresno, California, United States

Site Status

Pfizer Investigational Site

Fresno, California, United States

Site Status

Pfizer Investigational Site

Huntington Beach, California, United States

Site Status

Pfizer Investigational Site

Newhall, California, United States

Site Status

Pfizer Investigational Site

Orange, California, United States

Site Status

Pfizer Investigational Site

Paramount, California, United States

Site Status

Pfizer Investigational Site

Pico Rivera, California, United States

Site Status

Pfizer Investigational Site

Bridgeport, Connecticut, United States

Site Status

Pfizer Investigational Site

Hartford, Connecticut, United States

Site Status

Pfizer Investigational Site

Chicago, Illinois, United States

Site Status

Pfizer Investigational Site

Chicago, Illinois, United States

Site Status

Pfizer Investigational Site

Evanston, Illinois, United States

Site Status

Pfizer Investigational Site

Bardstown, Kentucky, United States

Site Status

Pfizer Investigational Site

Springfield, Kentucky, United States

Site Status

Pfizer Investigational Site

Pittsburgh, Pennsylvania, United States

Site Status

Pfizer Investigational Site

Dallas, Texas, United States

Site Status

Pfizer Investigational Site

Payson, Utah, United States

Site Status

Pfizer Investigational Site

Springville, Utah, United States

Site Status

Pfizer Investigational Site

Vienna, Virginia, United States

Site Status

Pfizer Investigational Site

Buenos Aires, , Argentina

Site Status

Pfizer Investigational Site

Independencia, Santiago Metropolitan, Chile

Site Status

Pfizer Investigational Site

Recoleta, Santiago Metropolitan, Chile

Site Status

Pfizer Investigational Site

Santiago, , Chile

Site Status

Pfizer Investigational Site

San José, Provincia de San José, Costa Rica

Site Status

Pfizer Investigational Site

Santo Domingo, DN, Dominican Republic

Site Status

Pfizer Investigational Site

Pärsti Vald, Viljandimaa, Estonia

Site Status

Pfizer Investigational Site

Rakvere, , Estonia

Site Status

Pfizer Investigational Site

Tallinn, , Estonia

Site Status

Pfizer Investigational Site

Tartu, , Estonia

Site Status

Pfizer Investigational Site

Guatemala City, Departamento de Guatemala, Guatemala

Site Status

Pfizer Investigational Site

Haifa, , Israel

Site Status

Pfizer Investigational Site

Jerusalem, , Israel

Site Status

Pfizer Investigational Site

Petah Tikva, , Israel

Site Status

Pfizer Investigational Site

Tel Litwinsky, , Israel

Site Status

Pfizer Investigational Site

Chihuahua City, Chihuahua, Mexico

Site Status

Pfizer Investigational Site

Panama City, , Panama

Site Status

Pfizer Investigational Site

Chorzów, , Poland

Site Status

Pfizer Investigational Site

Lublin, , Poland

Site Status

Pfizer Investigational Site

Moscow, , Russia

Site Status

Pfizer Investigational Site

Moscow, , Russia

Site Status

Pfizer Investigational Site

Smolensk, , Russia

Site Status

Pfizer Investigational Site

Košice, Slovakia, Slovakia

Site Status

Pfizer Investigational Site

Martin, Slovakia, Slovakia

Site Status

Pfizer Investigational Site

, ,

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Argentina Chile Costa Rica Dominican Republic Estonia Guatemala Israel Mexico Panama Poland Russia Slovakia

Related Links

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

A0661073

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Zmax Compared to Augmentin in Sinusitis
NCT00367120 COMPLETED PHASE4
TELI TON - Telithromycin in Tonsillitis
NCT00315042 TERMINATED PHASE3
Azithromycin 600 Mg Tablets, Fed
NCT00834132 COMPLETED PHASE1