Study Results
Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.
View full resultsBasic Information
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COMPLETED
PHASE4
22 participants
INTERVENTIONAL
2004-01-31
2008-07-31
Brief Summary
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Subjects will be randomized to one of the two beta-blockers and followed for 5 months. Each subject will undergo 4 inpatient studies where an oral glucose tolerance test will be done, Inflammatory and oxidative stress markers will be measured. Endothelial function will be measured using brachial artery ultrasound and laser skin Doppler
Detailed Description
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Subjects will be randomized to one of the two beta-blockers and followed for 5 months. Each subject will undergo 4 inpatient studies where an oral glucose tolerance test will be done, Inflammatory and oxidative stress markers will be measured. Endothelial function will be measured using brachial artery ultrasound and laser skin Doppler. Baseline visit will be done when subjects are off all antihypertension medications except ACEI/ARB. Following the baseline study subjects will be randomized to study drug. The dose will be titrated until goal blood pressure is reached. Add on medication will be used if needed.
Subjects will then undergo a second study. The third study will take place after 5 months on treatment. Stud drug will then be stoppped and subjects will be restudied 2 weeks later
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
TRIPLE
Study Groups
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1
study drug- carvedilol
carvedilol
variable
2
study drug metorprolol
metoprolol
variable
Interventions
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carvedilol
variable
metoprolol
variable
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
45 Years
85 Years
ALL
No
Sponsors
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University of New Mexico
OTHER
Responsible Party
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Locations
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UNMHSC
Albuquerque, New Mexico, United States
Countries
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References
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Colleran K, Aguirre L, Burge MR. Carvedilol vs. metoprolol: A comparison of effects on endothelial function and oxidative stress in response to acute hyperglycemia in patients with type 2 diabetes and hypertension. Journal of Diabetes Mellitus 2(1):146-151, 2012.
Other Identifiers
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UNM04094
Identifier Type: -
Identifier Source: org_study_id