Safety and Efficacy Study of Pitavastatin in Patient With a Metabolic Syndrome

NCT ID: NCT00640276

Last Updated: 2012-03-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

187 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-04-30

Study Completion Date

2011-06-30

Brief Summary

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We will identify the influence of long-term treatment of Pitavastatin compared to non-treatment control group on the metabolic syndrome by evaluation of a change of metabolic syndrome component score. And we will additionally observe the changes of CVD risk factors like lipid profile, abdominal fat, insulin resistance and so on.

Detailed Description

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Conditions

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Hypercholesterolemia Metabolic Syndrome

Keywords

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pitavastatin metabolic syndrome metabolic syndrome risk score hypercholesterolemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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T

Lifestyle modification + active drug(Pitavastatin)

Group Type ACTIVE_COMPARATOR

pitavastatin

Intervention Type DRUG

Pitavastatin 2mg daily once

C

Lifestyle Modification

Group Type OTHER

Lifestyle Modification

Intervention Type BEHAVIORAL

conducting mainly exercises and diet

Interventions

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pitavastatin

Pitavastatin 2mg daily once

Intervention Type DRUG

Lifestyle Modification

conducting mainly exercises and diet

Intervention Type BEHAVIORAL

Other Intervention Names

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Livaro

Eligibility Criteria

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Inclusion Criteria

* Patients aged between 18 and 75
* Patients with LDL ≥ 100mg/dL
* Patients with metabolic syndrome

1. IFG: Fasting glucose ≥ 100mg/dL
2. Abdominal Obesity: Waist circumference: men≥90cm,women≥85cm
3. 1 or more of the following

1. Triglyceride ≥ 150mg/dL
2. HDL-C: men \< 40mg/dL, women \< 50mg/dL
3. Blood pressure: SBP ≥ 130mmHg or DBP ≥ 85mmHg or subject receiving anti-hypertensive treatment

Exclusion Criteria

* uncontrolled hypertension (DBP ≥ 95mmHg)
* taking diabetic drugs or with HbA1c \> 8%
* LDL ≥ 190mg/dL or Triglyceride ≥ 400mg/dL
* coronary heart disease or other diseases caused by artherosclerosis
* malignancy within 6 months
* Serum creatinine ≥ 2.0mg/dL
* ALT or AST ≥ ULN\*2.5
* CPK ≥ ULN\*2
* hypothyroidism
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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JW Pharmaceutical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Chang Beom Lee

Role: STUDY_CHAIR

Hanyang Univ. Guri Hospital

Hak Chul Jang

Role: STUDY_CHAIR

Seoul National University Bundang Hospital

Locations

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Seoul National University Bundang Hospital

Bundang-gu, Gyeonggi-do, South Korea

Site Status

Hanyang Univ. Guri Hospital

Guri-si, Gyeonggi-do, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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CWP_PTV_706

Identifier Type: -

Identifier Source: org_study_id