Detection of Chemotherapy Induced Cardiotoxicity

NCT ID: NCT00636844

Last Updated: 2013-03-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

36 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-01-31

Study Completion Date

2012-06-30

Brief Summary

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To identify patients that are at risk of heart damage after receiving chemotherapy (adriamycin).

Detailed Description

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To identify patients at risk of development of heart damage after receiving chemotherapy by obtaining the genetic profile of those who show: elevation of troponin, left ventricular systolic and diastolic dysfunction, and pro-oxidant stress markers.

Conditions

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Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Group A

Patients receiving chemotherapy (anthracycline and/or adjuvant trastuzumab) for the first time

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* undergoing anthracycline and/or trastuzumab therapy for the first time

Exclusion Criteria

* abnormal ventricular ejection fraction
* past history of, or active cardiac disease including: MI, CHF, angina, arrhythmia requiring medication, valvular disease, uncontrolled systemic hypertension
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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George Washington University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jannet Lewis, MD

Role: PRINCIPAL_INVESTIGATOR

George Washington University

Locations

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George Washington University

Washington D.C., District of Columbia, United States

Site Status

Countries

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United States

Other Identifiers

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JL-001

Identifier Type: -

Identifier Source: org_study_id

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