Multicenter Assessment of the PDA-FIT System in Type 1 Diabetic Patients

NCT ID: NCT00629304

Last Updated: 2012-02-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

180 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-09-30

Study Completion Date

2009-08-31

Brief Summary

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TELEDIAB-1 is a national, multicenter, controlled, randomised trial. The Primary objective of the TELEDIAB-1 study is to demonstrate that the PDA-FIT system (PDA-Phone and/or telemonitoring) is able to improve metabolic control of chronically uncontrolled type 1 diabetic patients, despite intensive insulin therapy (multiple daily injections with basal-bolus insulin or insulin pump), as compared with conventional care.

Main judgment criteria: comparison of HbA1c means between the 3 groups at 6 months

Detailed Description

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Secondary Objectives :

1. To assess the improvement of blood glucose control and quality of life in patients using the PDA-FIT system
2. To assess the improvement in diabetes care provided by the use of the PDA-FIT system
3. Satisfaction of patients and physicians towards the PDA-FIT system

Conditions

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Type 1 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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1

standard visit at 3 and 6 months

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DEVICE

Patients will have face to face visits at 3 and 6 months and no PDA-FIT system. Patients will record glycemia on paper support.

2

PDA-FIT system + standard visit at 3 and 6 months

Group Type ACTIVE_COMPARATOR

VISITS + PDA-FIT system

Intervention Type DEVICE

patients will have face to face visits at 3 and 6 months + PDA-FIT system

3

PDA-FIT system + 12 telephone visits + standard visit at 6 months

Group Type ACTIVE_COMPARATOR

PDA-FIT System + telephone follow-up

Intervention Type DEVICE

patients will received PDA-FIT system + a telephone follow up (12 phone calls) and a face to face visit at 6 months

Interventions

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placebo

Patients will have face to face visits at 3 and 6 months and no PDA-FIT system. Patients will record glycemia on paper support.

Intervention Type DEVICE

VISITS + PDA-FIT system

patients will have face to face visits at 3 and 6 months + PDA-FIT system

Intervention Type DEVICE

PDA-FIT System + telephone follow-up

patients will received PDA-FIT system + a telephone follow up (12 phone calls) and a face to face visit at 6 months

Intervention Type DEVICE

Other Intervention Names

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paper support for glycemia face to face visits at 3 and 6 months without PDA-FIT system face to face visits at 3 and 6 months PDA-FIT system face to face visit at 6 months telephone visits each 2 weeks PDA-FIT system

Eligibility Criteria

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Inclusion Criteria

* type 1 diabetes mellitus for ≥ 12 months or more (including C-peptide negative secondary diabetes)
* age \> 18 y.o.
* intensive insulin basal-bolus therapy for ≥ 6 months. At inclusion, patients should be treated, either with a combination of a basal, long-acting insulin and insulin rapid analog before each meal, or with rapid insulin analog delivered with a pump
* chronically uncontrolled diabetes with HbA1c ≥ 8 % during the past 12 months and at inclusion

Exclusion Criteria

* patient with unstable associated evolutive pathology
* patient who need a more frequent diabetic follow up (than in the protocol)
* patient with a education teaching within the 3 months before inclusion
* patient with a hemoglobinopathy
* patient with toxicomania, alcoholism or psychological troubles
* type 2 diabetes patients
* patient who don't need strict metabolic objectives
* pregnant or parturient women
* person with no freedom (prisoner)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Grenoble

OTHER

Sponsor Role collaborator

Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pierre Yves BENHAMOU, MD PHD

Role: STUDY_CHAIR

University Hospital, Grenoble

Locations

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Centre Hospitalier de Belfort Montbéliard

Belfort, Belfort, France

Site Status

CHU Jean Minjoz

Besançon, Besancon, France

Site Status

CH SUD Francilien

Corbeil-Essonnes, Corbeil Essonnes, France

Site Status

University Hospital Grenoble

Grenoble, Grenoble, France

Site Status

CHRU Lille

Lille, Lille, France

Site Status

Hopital Edouard Herriot

Lyon, Lyon, France

Site Status

CHU Marseille Hôpitaux Sud

Marseille, Marseille, France

Site Status

Chu Montpellier

Montpellier, Montpellier, France

Site Status

CHU Hôpital Jeanne d'Arc

Nancy, Nancy, France

Site Status

CHU Nantes

Nantes, Nantes, France

Site Status

Hopital Hotel Dieu

Paris, Paris, France

Site Status

Hopital COCHIN

Paris, Paris, France

Site Status

HOPITAL Saint Louis

Paris, Paris, France

Site Status

Hopital Haut Leveque

Pessac, Pessac, France

Site Status

CHU Rennes

Rennes, Rennes, France

Site Status

Hopital Bellevue

Saint-Etienne, Saint Etienne, France

Site Status

Centre Hospitalier Strasbourg

Strasbourg, Strasbourg, France

Site Status

CHU Toulouse

Toulouse, Toulouse, France

Site Status

Countries

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France

References

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Charpentier G, Benhamou PY, Dardari D, Clergeot A, Franc S, Schaepelynck-Belicar P, Catargi B, Melki V, Chaillous L, Farret A, Bosson JL, Penfornis A; TeleDiab Study Group. The Diabeo software enabling individualized insulin dose adjustments combined with telemedicine support improves HbA1c in poorly controlled type 1 diabetic patients: a 6-month, randomized, open-label, parallel-group, multicenter trial (TeleDiab 1 Study). Diabetes Care. 2011 Mar;34(3):533-9. doi: 10.2337/dc10-1259. Epub 2011 Jan 25.

Reference Type DERIVED
PMID: 21266648 (View on PubMed)

Other Identifiers

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DCIC 07 08

Identifier Type: -

Identifier Source: org_study_id

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