Velocity Vector Imaging in Patients With Moderate-to-Severe Aortic Regurgitation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-03-31

Study Completion Date

2008-05-31

Brief Summary

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Velocity Vector Imaging may provide reliable and detailed information on left ventricular segmental function in asymptomatic patients with moderate-to severe AR. This may help to identify subclinical myocardial dysfunction in order to operate early enough to prevent postoperative heart failure and restrict unnecessary early operation which could be associated with operative risks and mortality related to prosthetic valves.

Detailed Description

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Chronic aortic regurgitation (AR) is a progressive process which causes both left ventricular volume and pressure overload. While the volume overload is associated with the degree of the aortic regurgitant volume, the pressure overload occurs as a result of systemic hypertension developed due to increased stroke volume. In early stages, excentric hypertrophy occurs aiming to compensate the volume overload in the left ventricle. Therefore , ejection fraction remains in normal range despite the increasing volume overload. Left ventricular dilatation and impairment in ejection fraction only occur in the end stages of the disease. Asymptomatic patients with chronic aortic regurgitation (AR) have a good prognosis in the presence of preserved systolic function. Therefore it is a challenge to identify patients with subclinical left ventricular (LV) dysfunction. Velocity vector imaging (VVI) is a new echocardiographic method based on two dimensional gray scale imaging, which is angle independent and can provide more accurate data about cardiac function.

Conditions

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Aortic Regurgitation

Keywords

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Aortic regurgitation,velocity vector imaging

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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A

Patients with moderate-to-severe aortic regurgitation having normal left ventricular ejection fraction

No interventions assigned to this group

B

Age, sex and bodymass index matched healthy subjects

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Moderate-to-severe aortic regurgitation identified by Standard echocardiography.
* Chronic isolated aortic regurgitation
* Being asymptomatic ( Class 1 according to NYHA)
* Sinusal rhythm

Exclusion Criteria

* Ejection fraction \< 50%
* Mitral valve disease accompanied to aortic regurgitation (patients with over mild degree of mitral regurgitation and stenosis
* Aortic stenosis
* Previous myocardial infarction, or the patients with \>50% coronary occlusion in any of the coronary arteries.
* Cardiomyopathies
* AV conduction disorders
* Chronic renal or hepatic insufficiency
* Malignities

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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T.C. Istanbul Bilim University, Florence Nightingale Hospital

Principal Investigators

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Saide Aytekin, Professor

Role: PRINCIPAL_INVESTIGATOR

T.C. Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology

Locations

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TC.Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology

Istanbul, Sisli, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Sokmen G, Sokmen A, Duzenli A, Soylu A, Ozdemir K. Assessment of myocardial velocities and global function of the left ventricle in asymptomatic patients with moderate-to-severe chronic aortic regurgitation: a tissue Doppler echocardiographic study. Echocardiography. 2007 Jul;24(6):609-14. doi: 10.1111/j.1540-8175.2007.00438.x.

Reference Type BACKGROUND

PMID: 17584200 (View on PubMed)

Other Identifiers

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YT1977

Identifier Type: -

Identifier Source: org_study_id