Efficacy and Safety of Risedronate Therapy Administered 35 mg Once A Week in Men With Osteoporosis

NCT ID: NCT00619957

Last Updated: 2011-10-28

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

285 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-06-30

Study Completion Date

2007-05-31

Brief Summary

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Two year study to determine the safety and efficacy of weekly 35 mg Risedronate doses in men with osteoporosis followed by a two year follow-up study.

Detailed Description

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Conditions

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Other Osteoporosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

Placebo tablet once a week for 2 years followed by once a week Risedronate for 2 years

Group Type PLACEBO_COMPARATOR

Placebo tablet

Intervention Type DRUG

one placebo once a week for two years followed by one 35 mg risedronate once a week for two years

Risedronate

35 mg risedronate tablet once a week for 2 years followed by open label 35 mg risedronate once a week for 2 years

Group Type EXPERIMENTAL

Risedronate

Intervention Type DRUG

one 35 mg risedronate once a week for two years followed by one 35 mg risedronate once a week for two years

Interventions

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Placebo tablet

one placebo once a week for two years followed by one 35 mg risedronate once a week for two years

Intervention Type DRUG

Risedronate

one 35 mg risedronate once a week for two years followed by one 35 mg risedronate once a week for two years

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Documented osteoporosis of the femoral neck and lumbar spine

Exclusion Criteria

* BMI greater than or equal to 35
Minimum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Sanofi

INDUSTRY

Sponsor Role collaborator

Warner Chilcott

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dietrich Wenderoth, MD

Role: STUDY_DIRECTOR

Procter and Gamble

Locations

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Research Site

Palm Desert, California, United States

Site Status

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Lakewood, Colorado, United States

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Stuart, Florida, United States

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St Louis, Missouri, United States

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Research Facility

Cincinnati, Ohio, United States

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Portland, Oregon, United States

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Wyomissing, Pennsylvania, United States

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Research Facility

Concord, , Australia

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Heidelburg, , Australia

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Leuven, , Belgium

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Prague, , Czechia

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Angers, , France

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Lyon, , France

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Budapest, , Hungary

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Budapest, , Hungary

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Beirut, , Lebanon

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Rotterdam, , Netherlands

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Bialystok, , Poland

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Warsaw, , Poland

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Wroclaw, , Poland

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London, , United Kingdom

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Newcastle, , United Kingdom

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Sheffield, , United Kingdom

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Countries

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United States Australia Belgium Czechia France Hungary Lebanon Netherlands Poland United Kingdom

References

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Boonen S, Lorenc RS, Wenderoth D, Stoner KJ, Eusebio R, Orwoll ES. Evidence for safety and efficacy of risedronate in men with osteoporosis over 4 years of treatment: Results from the 2-year, open-label, extension study of a 2-year, randomized, double-blind, placebo-controlled study. Bone. 2012 Sep;51(3):383-8. doi: 10.1016/j.bone.2012.06.016. Epub 2012 Jun 30.

Reference Type DERIVED
PMID: 22750403 (View on PubMed)

Other Identifiers

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2001092 and 2001092 OL

Identifier Type: -

Identifier Source: org_study_id