A Multiple-Dose Study to Assess the Safety, Tolerability, and Steady State Pharmacokinetics of APD791 in Healthy Volunteers

NCT ID: NCT00619931

Last Updated: 2022-07-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-01-31

Study Completion Date

2008-06-30

Brief Summary

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The APD791-002 study is designed primarily to evaluate the safety, tolerability, and pharmacokinetics of APD791 when administered for 7 days to healthy adult subjects.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

APD791 or placebo

Group Type EXPERIMENTAL

APD791

Intervention Type DRUG

APD791 or matching placebo in escalating doses

2

APD791 or placebo

Group Type EXPERIMENTAL

APD791

Intervention Type DRUG

APD791 or matching placebo in escalating doses

3

APD791 or placebo

Group Type EXPERIMENTAL

APD791

Intervention Type DRUG

APD791 or matching placebo in escalating doses

4

APD791 or placebo

Group Type EXPERIMENTAL

APD791

Intervention Type DRUG

APD791 or matching placebo in escalating doses

5

APD791 or placebo

Group Type EXPERIMENTAL

APD791

Intervention Type DRUG

APD791 or matching placebo in escalating doses

Interventions

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APD791

APD791 or matching placebo in escalating doses

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy adult men and women, ages 19-45
* Non smokers

Exclusion Criteria

* History of a bleeding disorder
* Use of any drug known to have an effect on coagulation or clotting or any anti-platelet therapy within 2 weeks of the screening
* Recently donated blood or had significant blood loss
* Current use of a prescription medication
* Pregnant females
Minimum Eligible Age

19 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Arena Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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James Kisicki, MD

Role: PRINCIPAL_INVESTIGATOR

MDS Pharma Services

Christen M Anderson, MD, PhD

Role: STUDY_DIRECTOR

Arena Pharmaceuticals

Locations

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MDS Pharma Services

Lincoln, Nebraska, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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APD791-002

Identifier Type: -

Identifier Source: org_study_id

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