A Double-Blind Study of E5555 in Japanese Patients With Acute Coronary Syndrome

NCT ID: NCT00619164

Last Updated: 2013-05-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

240 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-11-30

Brief Summary

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The purpose of this study is to assess the safety and tolerability of E5555 in Japanese patients with acute coronary syndrome.

Detailed Description

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Conditions

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Acute Coronary Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

Group Type EXPERIMENTAL

E5555

Intervention Type DRUG

E5555, 50 mg (tablet), taken orally, once a day.

2

Group Type EXPERIMENTAL

E5555

Intervention Type DRUG

E5555, 100 mg (tablet), taken orally, once a day.

3

Group Type EXPERIMENTAL

E5555

Intervention Type DRUG

E5555, 200 mg (tablet), taken orally, once a day.

4

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo tablet taken orally, once a day.

Interventions

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E5555

E5555, 50 mg (tablet), taken orally, once a day.

Intervention Type DRUG

E5555

E5555, 100 mg (tablet), taken orally, once a day.

Intervention Type DRUG

E5555

E5555, 200 mg (tablet), taken orally, once a day.

Intervention Type DRUG

Placebo

Placebo tablet taken orally, once a day.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. 45 - 80 years old (at time of informed consent)
2. Male or female (females of childbearing potential must be contracepted)
3. Confirmed acute coronary syndrome

Exclusion Criteria

1. Unwilling or unable to provide informed consent
2. History of acquired or congenital bleeding disorder, coagulopathy, or platelet disorder
3. Recent trauma or major surgery
4. Evidence of active pathological bleeding at screening or history of gastrointestinal or genitourinary bleeding with unknown cause within 24 weeks prior to screening
5. History of intracranial bleeding or history of hemorrhagic retinopathy
6. History of New York Heart Association (NYHA) class III or IV congestive heart failure
7. Pregnant or lactating women
Minimum Eligible Age

45 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eisai Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Masaru Takeuchi

Role: STUDY_DIRECTOR

New Product Development, Clinical Research Center, Eisai Co., Ltd.

Locations

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Toyoake, Aichi-ken, Japan

Site Status

Fukuoka, Fukuoka, Japan

Site Status

Kasuga, Fukuoka, Japan

Site Status

Kitakyushu, Fukuoka, Japan

Site Status

Kurume, Fukuoka, Japan

Site Status

Gifu, Gifu, Japan

Site Status

Ōgaki, Gifu, Japan

Site Status

Fukuyama, Hiroshima, Japan

Site Status

Higashi-Hiroshima, Hiroshima, Japan

Site Status

Hiroshima, Hiroshima, Japan

Site Status

Sapporo, Hokkaido, Japan

Site Status

Amagasaki, Hyōgo, Japan

Site Status

Himaji, Hyōgo, Japan

Site Status

Kobe, Hyōgo, Japan

Site Status

Nishinomiya, Hyōgo, Japan

Site Status

Kagoshima, Kagoshima-ken, Japan

Site Status

Yokohama, Kanagawa, Japan

Site Status

Ōmura, Nakasaki, Japan

Site Status

Beppu, Oita Prefecture, Japan

Site Status

Urazoe, Okinawa, Japan

Site Status

Osaka, Osaka, Japan

Site Status

Wako, Saitama, Japan

Site Status

Komatsushimachō, Tokushima, Japan

Site Status

Bunkyo, Tokyo, Japan

Site Status

Fuchū, Tokyo, Japan

Site Status

Hachiōji, Tokyo, Japan

Site Status

Kodaira, Tokyo, Japan

Site Status

Nerima City, Tokyo, Japan

Site Status

Shinagawa-ku, Tokyo, Japan

Site Status

Shinagawa, Tokyo, Japan

Site Status

Shinjuku, Tokyo, Japan

Site Status

tabashi City, Tokyo, Japan

Site Status

Tanabe, Wakayama, Japan

Site Status

Countries

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Japan

Other Identifiers

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E5555-J081-207

Identifier Type: -

Identifier Source: org_study_id

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