Avastin, Fluorouracil, Doxorubicin and Streptozocin in Locally Advanced and Metastatic Pancreatic Endocrine Tumors

NCT ID: NCT00609765

Last Updated: 2017-03-23

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 1 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2007-08-31
• Study Completion Date: 2008-03-31

Brief Summary

Open label, single-arm phase II study of avastin combined with fluorouracil, doxorubicin and streptozocin administered in 28-day cycles. Treatment will continue until progression of disease, or until withdrawal due to toxicity, or up to a maximum of 12 cycles (48 weeks). In order to reduce the risk of cardiac toxicity, doxorubicin will be administered for a maximum of 8 cycles. If disease has not progressed after 12 cycles of treatment, avastin monotherapy will continue until disease progression or withdrawal due to toxicity.

Detailed Description

Patients will need to come for 24 study visits in all. Most study visits will take about 2 hours. At some of these study visits, the doctor

• Will do a physical exam
• Will take blood for routine lab tests
• Will do a urinalysis
• Will administer study medication Some study visits may be longer because patient will have a CT scan or an MRI.

At patient's last visit, they will have a CT scan or MRI.

After treatment starts, patient will:

• Have their blood pressure monitored with every dose of Avastin® (about every 2 weeks).
• Have a history and physical with every chemotherapy cycle (about every 4 weeks).
• Have their blood taken for routine blood tests with every chemotherapy cycle (about every 4 weeks).
• Have a CT scan or MRI during every other cycle (about every 8 weeks).
• Have a MUGA scan during every 4 cycles (about 16 weeks).
• Have blood taken for tumor markers during every cycle only if their markers were high at baseline.
• Patients will receive study medication to treat their cancer:
• Fluorouracil on days 1 through 5 of each cycle through cycle 12
• Doxorubicin on day 1 of each cycle through cycle 8
• Streptozocin on days 1 through 5 of each cycle through cycle 12
• Avastin® on days 1 and 15 of each cycle through cycle 12

Conditions

Pancreatic Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Protocol Specified Chemotherapy

Protocol Specified Chemotherapy Every 28 Days: Avastin, Fluorouracil, Doxorubicin, Streptozocin.

Premedications: Dexamethasone, Ondansetron

Group Type: EXPERIMENTAL

Avastin

Intervention Type: DRUG

Every 28 Days: Avastin 5mg/kg iv days 1 and 15

Fluorouracil

Intervention Type: DRUG

Every 28 Days: Fluorouracil 400mg/m\^2 iv bolus daily days 1-5

Doxorubicin

Intervention Type: DRUG

Every 28 Days: Doxorubicin 40mg/m\^2 iv bolus day 1

Streptozocin

Intervention Type: DRUG

Every 28 Days: Streptozocin 400mg/m2 iv bolus daily days 1-5

Dexamethasone

Intervention Type: DRUG

Premedication: Dexamethasone 20mg intravenously days 1-5

Ondansetron

Intervention Type: DRUG

Premedication: Ondansetron 16mg intravenously days 1-5

Interventions

Avastin

Every 28 Days: Avastin 5mg/kg iv days 1 and 15

Intervention Type: DRUG

Fluorouracil

Every 28 Days: Fluorouracil 400mg/m\^2 iv bolus daily days 1-5

Intervention Type: DRUG

Doxorubicin

Every 28 Days: Doxorubicin 40mg/m\^2 iv bolus day 1

Intervention Type: DRUG

Streptozocin

Every 28 Days: Streptozocin 400mg/m2 iv bolus daily days 1-5

Intervention Type: DRUG

Dexamethasone

Premedication: Dexamethasone 20mg intravenously days 1-5

Intervention Type: DRUG

Ondansetron

Premedication: Ondansetron 16mg intravenously days 1-5

Intervention Type: DRUG

Other Intervention Names

bevacizumab; Fluoroplex; 5-FU; Efudex; Adriamycin®; Zanosar®; Decadron; Zofran

Eligibility Criteria

Inclusion Criteria

• Patients must have locally advanced (unresectable) or metastatic, well or moderately differentiated pancreatic endocrine tumors.
• Measurable disease on CT scan or MRI.
• Age ≥ 18 years and ≤ 80 years.
• Use of effective means of contraception (men and women) in subjects of child-bearing potential
• Adequate renal function (serum creatinine ≤1.5, urine protein:creatinine ratio <1.0 or urine dipstick for proteinuria < 2+ (patients discovered to have ≥ 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate ≤ 1 g of protein in 24 hours to be eligible).
• Adequate hepatic function (bilirubin ≤2.0, AST and ALT ≤ 3x ULN.
• Adequate hematologic function (WBC ≥ 3,000, ANC ≥ 1500, platelets ≥ 100,000)

Exclusion Criteria

• Prior therapy with fluorouracil, doxorubicin, streptozocin or avastin
• Ejection fraction on MUGA <50%
• ECOG performance status > 2
• Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study other than a Genentech-sponsored avastin cancer study
• Inadequately controlled hypertension (defined as systolic blood pressure >150 and/or diastolic blood pressure > 100 mmHg on antihypertensive medications)
• Any prior history of hypertensive crisis or hypertensive encephalopathy
• Unstable angina
• New York Heart Association (NYHA) Grade II or greater congestive heart failure
• History of myocardial infarction or unstable angina within 6 months prior to study enrollment
• History of stroke or transient ischemic attack within 6 months prior to study enrollment
• Significant vascular disease (e.g., aortic aneurysm, aortic dissection)
• Symptomatic peripheral vascular disease
• Evidence of bleeding diathesis or coagulopathy
• Presence of central nervous system or brain metastases
• Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 0, anticipation of need for major surgical procedure during the course of the study
• Core biopsy or other minor surgical procedure, excluding placement of a vascular access device, within 7 days prior to study enrollment
• Pregnant (positive pregnancy test) or lactating. Use of effective means of contraception (men and women) in subjects of child-bearing potential
• Proteinuria at screening as demonstrated by either

• Urine protein: creatinine (UPC) ratio ≥ 1.0 at screening OR
• Urine dipstick for proteinuria ≥ 2+ (patients discovered to have ≥2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate ≤ 1g of protein in 24 hours to be eligible).
• History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to Day 0
• Evidence of duodenal invasion on CT scan, MRI, or endoscopy
• Known hypersensitivity to any component of avastin
• Serious, non-healing wound, ulcer, or bone fracture
• Inability to comply with study and/or follow-up procedures

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Genentech, Inc.

INDUSTRY

Sponsor Role: collaborator

H. Lee Moffitt Cancer Center and Research Institute

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Larry Kvols, M.D.

Role: PRINCIPAL_INVESTIGATOR

H. Lee Moffitt Cancer Center and Research Institute

Jonathan Strosberg, M.D.

Role: PRINCIPAL_INVESTIGATOR

H. Lee Moffitt Cancer Center and Research Institute

Locations

H. Lee Moffitt Cancer Center and Research Institute

Tampa, Florida, United States

Countries

United States

Other Identifiers

AVF3915s

Identifier Type: OTHER

Identifier Source: secondary_id

MCC-14961

Identifier Type: -

Identifier Source: org_study_id