Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2007-03-31
2008-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
DOUBLE
Study Groups
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1
sildenafil
50mg 3 times daily for 7 days
hydralazine
25mg 3 times daily for 7 days
placebo
3 times daily for 7 days
2
sildenafil
50mg 3 times daily for 7 days
hydralazine
25mg 3 times daily for 7 days
placebo
3 times daily for 7 days
Interventions
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sildenafil
50mg 3 times daily for 7 days
hydralazine
25mg 3 times daily for 7 days
placebo
3 times daily for 7 days
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Appropriate blood pressure range
* Hypertensive - Systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg
* Controls - Systolic BP \<140 mmHg and diastolic BP \<90mmHg
* Written informed consent
Exclusion Criteria
* History of coronary artery, cerebrovascular or peripheral vascular disease within the last 6 months
* Total cholesterol \>6.5 mmol/L
* Current alcohol abuse
* Diabetes mellitus
* Asthma
* Taking any anti-hypertensive, vasoactive or endothelial function modifying drugs which cannot be withdrawn for the purpose of the study
* ECG evidence of clinically significant arrhythmia or cardiac ischaemia
* Clinically significant abnormality on screening blood test
* Contraindication to strenuous exercise
* Current involvement in other research projects
* Other clinically relevant conditions
* Lack of written informed consent
18 Years
70 Years
MALE
Yes
Sponsors
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University of Edinburgh
OTHER
Responsible Party
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University of Edinburgh
Principal Investigators
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Teresa M Attinà, MD
Role: PRINCIPAL_INVESTIGATOR
University of Edinburgh
David J Webb, MD
Role: STUDY_DIRECTOR
University of Edinburgh
Locations
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University of Edinburgh - Western General Hospital
Edinburgh, , United Kingdom
Countries
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Other Identifiers
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LREC/2004/4/13
Identifier Type: -
Identifier Source: secondary_id
LREC/2004/4/13
Identifier Type: -
Identifier Source: org_study_id
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