A 52-Week Study of Bicifadine in Patients With Chronic Neuropathic Pain Associated With Diabetic Peripheral Neuropathy

NCT ID: NCT00597649

Last Updated: 2009-06-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE2

Total Enrollment

250 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-10-31

Study Completion Date

2008-12-31

Brief Summary

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This study is to evaluate the long-term efficacy and safety of two dosages of bicifadine SR (600 mg/day and 1200 mg/day) for up to 52 weeks in reducing chronic peripheral neuropathy pain due to diabetes in adult outpatients.

Detailed Description

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Conditions

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Chronic Peripheral Neuropathy Pain in Diabetics

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Bicifadine 800 mg/day for a year

Group Type EXPERIMENTAL

Bicifadine

Intervention Type DRUG

SR dosage form of 400 mg bid or tid for one year

2

Bicifadine 1200 mg/day for a year

Group Type EXPERIMENTAL

Bicifadine

Intervention Type DRUG

SR dosage form of 400 mg bid or tid for one year

Interventions

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Bicifadine

SR dosage form of 400 mg bid or tid for one year

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female
* 18 years or older
* Diagnosis of type 1 or type 2 non-insulin dependent diabetes mellitus
* Chronic bilateral pain due to diabetic neuropathy, pain for at least six months.
* Primary pain is located in the feet.
* Subject participated in and completed the XTL 07-001 clinical trial.

Contact site for additional information.

Exclusion Criteria

* Symptoms of other painful conditions
* Presence of amputations other than toes
* Clinically significant psychiatric or other neuropsychological disorder
* Use of certain medications
* Clinically important other diseases
* Pregnancy
* History of alcohol or narcotic abuse within two years.

Contact site for additional information.
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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XTL Biopharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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XTL Biopharmaceutical Co.

Principal Investigators

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Mark Roffman, PhD

Role: STUDY_DIRECTOR

XTL Biopharmaceuticals

Locations

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Four Rivers Clinical Research

Paducah, Kentucky, United States

Site Status

Countries

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United States

Related Links

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http://www.xtlbio.com

Sponsor's website

Other Identifiers

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2007-003638-40

Identifier Type: -

Identifier Source: secondary_id

XTL B07-002

Identifier Type: -

Identifier Source: org_study_id