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Monoamine Transporter Function and Autonomic Regulation During Psychodynamic Psychotherapy

NCT ID: NCT00594711

Last Updated: 2011-10-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

26 participants

Study Classification

OBSERVATIONAL

Study Start Date

2000-01-31

Study Completion Date

2008-12-31

Brief Summary

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Outcome of psychodynamic psychotherapy measured by \[123I\] nor-B-CIT SPET imaging

Background Psychodynamic psychotherapy is a widely practised form of psychotherapy in the treatment of depression. There is evidence that serotonin transporter (SERT) densities are altered in depression. Preliminary observations have suggested that SERT function may recover in connection with dynamic psychotherapy.

The objective was to determine whether SERT densities change in relation to clinical recovery during psychodynamic psychotherapy.

Detailed Description

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N=26

Method Twenty six drug-naïve currently depressed (moderate/severe) patients with no previous treatment were recruited for the study. The baseline study included a group of 18 healthy controls. The patients were randomised into psychotherapy and waiting-list control groups. For controls, psychotherapy was started after a 6-month waiting period. \[123I\] nor-B-CIT SPET imaging was performed at baseline and after 12 months of psychotherapy. For the controls, additional imaging was performed after the 6-month waiting period.

Conditions

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Depression

Keywords

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Psychotherapy depression

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Case-group

No interventions assigned to this group

2

Control-group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* depression

Exclusion Criteria

* antidepressive medication
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Eastern Finland

OTHER

Sponsor Role collaborator

Kuopio University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Taru Grohn

Pirjo Saarinen

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Pirjo Saarinen, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Kuopio University Hospital

Johannes Lehtonen, Ph.D

Role: STUDY_DIRECTOR

Kuopio University Hospital

Lehto Soili, MD

Role: STUDY_CHAIR

Kuopio University Hospital

Minna Valkonen-Korhonen, Ph.D

Role: STUDY_CHAIR

Kuopio University

Pasi Ahola, MD

Role: STUDY_CHAIR

Kuopio University

Mikko Joensuu, MD

Role: STUDY_CHAIR

Kuopio University Hospital

Tommi Tolmunen, Ph.D.

Role: STUDY_CHAIR

Kuopio University Hospital

References

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Joensuu M, Ahola P, Knekt P, Lindfors O, Saarinen P, Tolmunen T, Valkonen-Korhonen M, Vanninen R, Jaaskelainen T, Virtala E, Kuikka J, Tiihonen J, Lehtonen J. Baseline symptom severity predicts serotonin transporter change during psychotherapy in patients with major depression. Psychiatry Clin Neurosci. 2016 Jan;70(1):34-41. doi: 10.1111/pcn.12335. Epub 2015 Sep 22.

Reference Type DERIVED
PMID: 26311446 (View on PubMed)

Other Identifiers

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118/9/00

Identifier Type: -

Identifier Source: secondary_id

KUH5703410

Identifier Type: -

Identifier Source: org_study_id