An Open-Label Extension Trial to Assess the Safety of Long-Term Treatment of Rotigotine in Advance-Stage Parkinson's Disease

NCT ID: NCT00594386

Last Updated: 2014-10-02

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

258 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-08-31

Study Completion Date

2008-12-31

Brief Summary

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The objective of this open-label extension is to assess the safety and tolerability of long-term treatment of the Rotigotine patch in subjects with advanced-stage idiopathic Parkinson's Disease.

Detailed Description

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This is the open-label extension to the randomized, double-blind, placebo-controlled SP650 trial that assessed the efficacy and safety and tolerability of the Rotigotine patch in subjects with advanced-stage idiopathic Parkinson's Disease who are not well-controlled on Levodopa.

Conditions

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Parkinson's Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Rotigotine

Group Type EXPERIMENTAL

Rotigotine

Intervention Type DRUG

Rotigotine transdermal patches:

10 cm2 (2 mg/24 hours); 20 cm2 (4 mg/24 hours); 30 cm2 (6 mg/24 hours); 40 cm2 (8 mg/24 hours)

Optimal dosing:

During the first year: The maximum Rotigotine dose allowed is 6 mg/24 hours.

After the first year: Allowed dose increase of Rotigotine up to a maximum of 16 mg/24 hours.

Interventions

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Rotigotine

Rotigotine transdermal patches:

10 cm2 (2 mg/24 hours); 20 cm2 (4 mg/24 hours); 30 cm2 (6 mg/24 hours); 40 cm2 (8 mg/24 hours)

Optimal dosing:

During the first year: The maximum Rotigotine dose allowed is 6 mg/24 hours.

After the first year: Allowed dose increase of Rotigotine up to a maximum of 16 mg/24 hours.

Intervention Type DRUG

Other Intervention Names

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Neupro

Eligibility Criteria

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Inclusion Criteria

* Subjects who have completed six months of maintenance treatment in the SP650 double-blind trial

Exclusion Criteria

* Subjects who had an ongoing serious adverse event from the SP650 double-blind trial that was assessed as related to study medication
Minimum Eligible Age

31 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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UCB Pharma

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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UCB Clinical Trial Call Center

Role: STUDY_DIRECTOR

+1 877 822 9493 (UCB)

Locations

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Huntsville, Alabama, United States

Site Status

Peoria, Arizona, United States

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Phoenix, Arizona, United States

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Tucson, Arizona, United States

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Hot Springs, Arkansas, United States

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Fountain Valley, California, United States

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Fresno, California, United States

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Irvine, California, United States

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Los Angeles, California, United States

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Danbury, Connecticut, United States

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Fairfield, Connecticut, United States

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New Haven, Connecticut, United States

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Miami, Florida, United States

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Pompano Beach, Florida, United States

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St. Petersburg, Florida, United States

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Sunrise, Florida, United States

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Atlanta, Georgia, United States

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Hoffman Estates, Illinois, United States

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Fort Wayne, Indiana, United States

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Kansas City, Kansas, United States

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Lexington, Kentucky, United States

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Boston, Massachusetts, United States

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Southfield, Michigan, United States

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Minneapolis, Minnesota, United States

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Henderson, Nevada, United States

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Albany, New York, United States

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Forest Hills, New York, United States

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Louisville, New York, United States

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Asheville, North Carolina, United States

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Raleigh, North Carolina, United States

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Toledo, Ohio, United States

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Upland, Pennsylvania, United States

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Houston, Texas, United States

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San Antonio, Texas, United States

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Richmond, Virginia, United States

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Roanoke, Virginia, United States

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Milwaukee, Wisconsin, United States

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Edmonton, Alberta, Canada

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Ottawa, Ontario, Canada

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Montrél, Quebec, Canada

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Saskatoon, Saskatchewan, Canada

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Countries

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United States Canada

Related Links

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Other Identifiers

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SP0715

Identifier Type: -

Identifier Source: org_study_id

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