Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
3 participants
OBSERVATIONAL
2007-12-31
2010-08-31
Brief Summary
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Researchers also want to find out if other medical conditions, such as high blood sugar, high blood cholesterol, or history of tobacco use may contribute to the thickening or blockage of the carotid arteries.
Detailed Description
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If you agree to take part in this study, researchers will see if there are any possible effects (thickening or blockage) of radiation therapy on your carotid arteries. This will be done by examining the test results from routine testing (mentioned below) that is normally done for your standard long-term follow-up care of the disease. These routine tests would be performed even if you were not in this research study.
During your long-term follow-up clinic appointment, you will have a physical exam and an ultrasound test (performed at the Cardiology Clinic) of the carotid arteries. A carotid ultrasound is a test that uses sound waves to look at the blood vessels in the neck. Blood will be drawn (about 2-3 teaspoons) for laboratory tests, including blood sugar level, blood cholesterol level, blood triglyceride level, thyroid hormone level, and blood levels of certain proteins (C-reactive protein and brain natriuretic peptide).
If any of the tests show any thickening or blockage of the carotid arteries or other medical problems, such as high blood sugar, your study doctor will discuss the test results, treatment options, and/or a follow-up plan with you.
This is an investigational study. Up to 60 patients will take part in this study. All will be enrolled at M. D. Anderson.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Carotid Ultrasound
Carotid Ultrasound: Irradiated and non-irradiated sides of the neck in long-term survivors of pediatric cancers who received unilateral radiation therapy involving the carotid artery as part of their treatment
Carotid Ultrasound
Bilateral carotid ultrasound measurements: A test that uses sound waves to look at the blood vessels in the neck.
Interventions
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Carotid Ultrasound
Bilateral carotid ultrasound measurements: A test that uses sound waves to look at the blood vessels in the neck.
Eligibility Criteria
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Inclusion Criteria
2. Patients treated at M.D. Anderson Cancer Center for any malignancy (including primary CNS tumors) that required unilateral radiation therapy to the head and neck area and involving the ipsilateral carotid artery as part of the overall treatment plan.
3. Patients must be at least 5 years status post completion of therapy.
4. Must be English speaking, or able to consent through an approved medical language translator.
5. A written informed consent from the patient and/or the patient's legally authorized guardian must be obtained from all patients.
Exclusion Criteria
2. Non-English speaking subjects for which no appropriate medical translator is available
3. Patients who received head/neck radiation involving both carotid arteries will not be eligible.
21 Years
ALL
No
Sponsors
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M.D. Anderson Cancer Center
OTHER
Responsible Party
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Principal Investigators
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Winston Huh, MD
Role: PRINCIPAL_INVESTIGATOR
M.D. Anderson Cancer Center
Locations
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UT MD Anderson Cancer Center
Houston, Texas, United States
Countries
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Related Links
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UT MD Anderson Cancer Center
Other Identifiers
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2006-0487
Identifier Type: -
Identifier Source: org_study_id