Study to Evaluate if Inhaled Nitric Oxide Improves Liver Function After Transplantation
NCT ID: NCT00582010
Last Updated: 2014-11-06
Study Results
Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.
View full resultsBasic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
PHASE2/PHASE3
80 participants
INTERVENTIONAL
2008-04-30
2012-10-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Safety and Efficacy Study of Nitric Oxide in Patients Going Through Lung Transplantation
NCT00570245
Inhaled Nitric Oxide in Prevention/Treatment of Ischemia-Reperfusion Lung Injury Related to Lung Transplantation
NCT00060450
Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest
NCT03079102
Inhaled Selective Pulmonary Vasodilators for Advanced Heart Failure Therapies and Lung Transplantation Outcomes
NCT03081052
Inhaled Nitric Oxide in Pulmonary Embolism
NCT00565253
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
1. Experimental
iNO administration
inhaled nitric oxide
inhaled 80ppm for duration of surgery.
2. Placebo
Placebo (nitrogen)
nitrogen gas
inhaled
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
inhaled nitric oxide
inhaled 80ppm for duration of surgery.
nitrogen gas
inhaled
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
Exclusion Criteria
* Patients undergoing re-transplantation or dual organ transplantation
* Patients with underlying pulmonary complications
19 Years
80 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Mallinckrodt
INDUSTRY
University of Washington
OTHER
University of Alabama at Birmingham
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Rakesh Patel
Professor
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Rakesh P Patel, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Alabama at Birmingham
Keith A Jones, MD
Role: PRINCIPAL_INVESTIGATOR
University of Alabama at Birmingham
Devin E Eckhoff, MD
Role: PRINCIPAL_INVESTIGATOR
University of Alabama at Birmingham
John S Bynon, MD
Role: STUDY_DIRECTOR
University of Alabama at Birmingham
Blair Smith, MD
Role: STUDY_DIRECTOR
University of Alabama at Birmingham
Clark Cross, MD
Role: STUDY_CHAIR
University of Alabama at Birmingham
Luc Frenette, MD
Role: STUDY_DIRECTOR
University of Alabama at Birmingham
John D Lang, MD
Role: PRINCIPAL_INVESTIGATOR
University of Washington
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
University of Alabama at Birmingham
Birmingham, Alabama, United States
University of Washington
Seattle, Washington, United States
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Lang JD Jr, Teng X, Chumley P, Crawford JH, Isbell TS, Chacko BK, Liu Y, Jhala N, Crowe DR, Smith AB, Cross RC, Frenette L, Kelley EE, Wilhite DW, Hall CR, Page GP, Fallon MB, Bynon JS, Eckhoff DE, Patel RP. Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation. J Clin Invest. 2007 Sep;117(9):2583-91. doi: 10.1172/JCI31892.
Lang JD Jr, Smith AB, Brandon A, Bradley KM, Liu Y, Li W, Crowe DR, Jhala NC, Cross RC, Frenette L, Martay K, Vater YL, Vitin AA, Dembo GA, Dubay DA, Bynon JS, Szychowski JM, Reyes JD, Halldorson JB, Rayhill SC, Dick AA, Bakthavatsalam R, Brandenberger J, Broeckel-Elrod JA, Sissons-Ross L, Jordan T, Chen LY, Siriussawakul A, Eckhoff DE, Patel RP. A randomized clinical trial testing the anti-inflammatory effects of preemptive inhaled nitric oxide in human liver transplantation. PLoS One. 2014 Feb 12;9(2):e86053. doi: 10.1371/journal.pone.0086053. eCollection 2014.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
F070112003
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.