Psychological Influences on Postoperative Recovery

NCT ID: NCT00581139

Last Updated: 2023-09-07

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

241 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-04-30

Study Completion Date

2009-04-30

Brief Summary

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The primary hypothesis tested in this project is that the preoperative behavioral stress response predicts postoperative behavioral and clinical recovery of children undergoing surgery.

Detailed Description

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Conditions

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Care, Postoperative Pain, Postoperative Surgical Procedures, Operative Otorhinolaryngologic Surgical Procedures Tonsillectomy Adenoidectomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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1

Group Type ACTIVE_COMPARATOR

Preoperative Preparation Program (Child Life Specialist)

Intervention Type BEHAVIORAL

This group will receive the standard preoperative visit to the hospital with Child Life intervention

2

Group Type ACTIVE_COMPARATOR

Midazolam

Intervention Type DRUG

0.5 mg/kg oral midazolam

3

Group Type ACTIVE_COMPARATOR

Parental Presence during Induction of Anesthesia

Intervention Type BEHAVIORAL

One parent will be present during induction of anesthesia of the child. The parent will be accompanied out of the OR by a nurse once the induction is completed. These parents will have completed a parent preparation program.

4

Group Type ACTIVE_COMPARATOR

PPIA preparation program PLUS Midazolam premedication

Intervention Type OTHER

Subjects in this group will receive both interventions 2 and 3.

Interventions

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Preoperative Preparation Program (Child Life Specialist)

This group will receive the standard preoperative visit to the hospital with Child Life intervention

Intervention Type BEHAVIORAL

Midazolam

0.5 mg/kg oral midazolam

Intervention Type DRUG

Parental Presence during Induction of Anesthesia

One parent will be present during induction of anesthesia of the child. The parent will be accompanied out of the OR by a nurse once the induction is completed. These parents will have completed a parent preparation program.

Intervention Type BEHAVIORAL

PPIA preparation program PLUS Midazolam premedication

Subjects in this group will receive both interventions 2 and 3.

Intervention Type OTHER

Other Intervention Names

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Versed PPIA Preparation Program

Eligibility Criteria

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Inclusion Criteria

* Outpatient tonsillectomy or tonsils/adenoids
* ASA I, II

Exclusion Criteria

* Developmental delay
* ASA III-IV
* Psychotropic medication
* Meds which interfere with metabolism of midazolam
* 36 weeks gestation
Minimum Eligible Age

3 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institutes of Health (NIH)

NIH

Sponsor Role collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

Sponsor Role collaborator

University of California, Irvine

OTHER

Sponsor Role lead

Responsible Party

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Zeev Kain

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Zeev N Kain, MD, MBA

Role: PRINCIPAL_INVESTIGATOR

Yale University Department of Anesthesiology

Locations

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Yale University Department of Anesthesiology

New Haven, Connecticut, United States

Site Status

Countries

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United States

Other Identifiers

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R01HD037007-01

Identifier Type: NIH

Identifier Source: secondary_id

View Link

9801009972 [2008-6723]

Identifier Type: -

Identifier Source: org_study_id

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