Albuterol HFA MDI in Pediatric Participants With Asthma

NCT ID: NCT00577655

Last Updated: 2021-11-12

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

103 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-08-31

Study Completion Date

2008-07-31

Brief Summary

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The primary objective of this study is to evaluate the chronic-dose and efficacy of Albuterol-HFA-MDI relative to placebo in pediatric asthmatics.

Detailed Description

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Conditions

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Asthma

Keywords

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Pediatric, asthma, albuterol-HFA and Placebo

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Albuterol

Albuterol-HFA-MDI 180 mcg, four times a day (total daily albuterol dose of 720 mcg) for 21 days. HFA-MDI refers to a metered-dose inhaler (MDI) utilizing a hydrofluoroalkane (HFA) propellant.

Group Type EXPERIMENTAL

Albuterol

Intervention Type DRUG

Albuterol HFA MDI 180 mcg four times a day (q.i.d) for a total daily albuterol dose of 720 mcg for 21 days.

Proventil® HFA

Intervention Type DRUG

Proventil® HFA (albuterol sulfate) Inhalation Aerosol (Key Pharmaceuticals) was used as rescue medication in this study. The rescue medication was over-labeled with instructions for emergency use in which subjects were instructed to self-administer up to two puffs every 20 minutes to a maximum of six puffs for any given episode while attempting to seek medical assistance.

Placebo

A placebo of a metered-dose inhaler (MDI) utilizing a hydrofluoroalkane (HFA) propellant. (Hereafter noted as "Placebo-HFA-MDI.")

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo HFA MDI four times a day (q.i.d) for 21 days.

Proventil® HFA

Intervention Type DRUG

Proventil® HFA (albuterol sulfate) Inhalation Aerosol (Key Pharmaceuticals) was used as rescue medication in this study. The rescue medication was over-labeled with instructions for emergency use in which subjects were instructed to self-administer up to two puffs every 20 minutes to a maximum of six puffs for any given episode while attempting to seek medical assistance.

Interventions

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Albuterol

Albuterol HFA MDI 180 mcg four times a day (q.i.d) for a total daily albuterol dose of 720 mcg for 21 days.

Intervention Type DRUG

Placebo

Placebo HFA MDI four times a day (q.i.d) for 21 days.

Intervention Type DRUG

Proventil® HFA

Proventil® HFA (albuterol sulfate) Inhalation Aerosol (Key Pharmaceuticals) was used as rescue medication in this study. The rescue medication was over-labeled with instructions for emergency use in which subjects were instructed to self-administer up to two puffs every 20 minutes to a maximum of six puffs for any given episode while attempting to seek medical assistance.

Intervention Type DRUG

Other Intervention Names

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ProAir® HFA Albuterol Sulfate albuterol sulfate

Eligibility Criteria

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Inclusion Criteria

* Male and female child aged 4-11 years, inclusive Asthma of a minimum of six months duration that has been stable for at least four weeks prior to screening.

Exclusion Criteria

* Hospitalization for acute asthma exacerbation greater than two years in 12 months prior to screening and/or received ER treatment or hospitalization for asthma exacerbation.
Minimum Eligible Age

4 Years

Maximum Eligible Age

11 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Teva Branded Pharmaceutical Products R&D, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Teva Study Physician MD

Role: STUDY_DIRECTOR

Teva Branded Pharmaceutical Products R&D, Inc.

Locations

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Pediatric Care Medical Group, Inc.

Huntington Beach, California, United States

Site Status

California Allergy & Asthma Medical Group

Palmdale, California, United States

Site Status

Center for Clinical Trials, LLC

Paramount, California, United States

Site Status

Integrated Research Group, Inc

Riverside, California, United States

Site Status

Center for Clinical Trials of Sacramento

Sacramento, California, United States

Site Status

Carlos Piniella, MD

Miami, Florida, United States

Site Status

Sneeze, Wheeze & Itch Associates, Inc.

Normal, Illinois, United States

Site Status

Asthma & Allergy Associates, PC

Elmira, New York, United States

Site Status

ENT & Allergy Associates

Newburgh, New York, United States

Site Status

St. Elizabeth's Children Health Center

Utica, New York, United States

Site Status

Regional Allergy & Asthma Consultants

Asheville, North Carolina, United States

Site Status

Clinical Research Institute of Southern Oregan, PC

Medford, Oregon, United States

Site Status

Virginia Adult & Pediatric Allergy & Asthma

Richmond, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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IXR-302-25-105

Identifier Type: -

Identifier Source: org_study_id