Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
100 participants
INTERVENTIONAL
2002-03-31
2006-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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I
Adenosine 5'-triphosphate
Weekly ATP infusions (in total 8 infusions) during 8 - 12 hours in a maximum dose of 50 mcg/kg.min
C
No interventions assigned to this group
Interventions
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Adenosine 5'-triphosphate
Weekly ATP infusions (in total 8 infusions) during 8 - 12 hours in a maximum dose of 50 mcg/kg.min
Eligibility Criteria
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Inclusion Criteria
* medical treatment options restricted to supportive care
* a life expectancy \< 6 months
* World Health Organization (WHO) performance status 1 or 2
* suffering from at least one of the following complaints: fatigue, weight loss \> 5% over the last 6 months, or anorexia
Exclusion Criteria
* symptomatic heart failure
* any form of atrioventricular (AV) block (assessed by electrocardiogram)
* life expectancy \< 4 weeks
* concurrent palliative chemotherapy
* cognitive dysfunction, and other diseases hampering adequate follow up
18 Years
ALL
No
Sponsors
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ZonMw: The Netherlands Organisation for Health Research and Development
OTHER
Maastricht University Medical Center
OTHER
Principal Investigators
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P.C. Dagnelie, PhD
Role: PRINCIPAL_INVESTIGATOR
Maastricht University - Department of Epidemiology
Locations
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Maxima Medical Center
Eindhoven, , Netherlands
Catharina Hospital Eindhoven
Eindhoven, , Netherlands
Atrium MC
Heerlen, , Netherlands
Maastricht University Hospital
Maastricht, , Netherlands
University Medical Center Utrecht
Utrecht, , Netherlands
Countries
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References
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Agteresch HJ, Dagnelie PC, van der Gaast A, Stijnen T, Wilson JH. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst. 2000 Feb 16;92(4):321-8. doi: 10.1093/jnci/92.4.321.
Agteresch HJ, Rietveld T, Kerkhofs LG, van den Berg JW, Wilson JH, Dagnelie PC. Beneficial effects of adenosine triphosphate on nutritional status in advanced lung cancer patients: a randomized clinical trial. J Clin Oncol. 2002 Jan 15;20(2):371-8. doi: 10.1200/JCO.2002.20.2.371.
Agteresch HJ, Burgers SA, van der Gaast A, Wilson JH, Dagnelie PC. Randomized clinical trial of adenosine 5'-triphosphate on tumor growth and survival in advanced lung cancer patients. Anticancer Drugs. 2003 Sep;14(8):639-44. doi: 10.1097/00001813-200309000-00009.
Other Identifiers
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ZonMW 1135.0010
Identifier Type: -
Identifier Source: secondary_id
MEC 01-092.3
Identifier Type: -
Identifier Source: org_study_id
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