A Study to Investigate the Influence of MK0859 on Blood Pressure (MK-0859-012)(COMPLETED)

NCT ID: NCT00565006

Last Updated: 2015-02-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-07-31

Study Completion Date

2006-09-30

Brief Summary

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This study will investigate the influence of MK0859 on ambulatory blood pressure, and how safe and tolerable MK0859 is on the subjects This is an early phase trial and some specific protocol information is in progress and not publicly available at this time. (Full information is available to trial participants).

Detailed Description

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Conditions

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Ambulatory Blood Pressure

Interventions

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MK0859

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* You are between the ages of 45-75
* You are a man or non-pregnant woman
* You agree to not eat or drink fruit or fruit juices (orange, apple or grapefruit) for 2 weeks before starting study medication

Exclusion Criteria

* You have smoked or used other nicotine-containing products (chewing tobacco) within the last 6 months
* You have used St. John's Wort or any products that include it within the last 2 weeks
* You have used herbal, organic, dietary or nutritional remedies within the last 2 weeks
* You have a history of drug allergies (anaphylaxis, angioedema)
* You have taken an investigational drug in another clinical trial within the last 4 weeks
* You have a history of cardiovascular disease including hypertension (high blood pressure)
* You have a history of renal disease
* You have a history of gall bladder disease or have had abnormal liver function tests
* You have a history of drug or alcohol abuse
* You drink more than 6 cups of caffeinated beverages a day (coffee, tea or cola)
Minimum Eligible Age

45 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Monitor

Role: STUDY_DIRECTOR

Merck Sharp & Dohme LLC

References

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Krishna R, Anderson MS, Bergman AJ, Jin B, Fallon M, Cote J, Rosko K, Chavez-Eng C, Lutz R, Bloomfield DM, Gutierrez M, Doherty J, Bieberdorf F, Chodakewitz J, Gottesdiener KM, Wagner JA. Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studies. Lancet. 2007 Dec 8;370(9603):1907-14. doi: 10.1016/S0140-6736(07)61813-3.

Reference Type DERIVED
PMID: 18068514 (View on PubMed)

Other Identifiers

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2007_656

Identifier Type: -

Identifier Source: secondary_id

0859-012

Identifier Type: -

Identifier Source: org_study_id

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