Safety and Effect of Oral Doses of 5mg or 10mg of SLx-2101 for 14 Days in Patients With Hypertension

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

38 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-06-30

Study Completion Date

2007-12-31

Brief Summary

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The purpose is to determine the effect of SLx-2101 dosed at 5mg or 10mg for 14 days on systolic, diastolic pressures and heart rate in patients with hypertension.

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Detailed Description

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1. Placebo-corrected supine peripheral systolic, diastolic blood pressures and heart rate
2. 24 hour ambulatory blood pressure and heart rate
3. Safety and tolerability

Conditions

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Hypertension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

SLx-2101

Group Type EXPERIMENTAL

SLx-2101

Intervention Type DRUG

2

Comparative Placebo Dose

Group Type PLACEBO_COMPARATOR

SLx-2101

Intervention Type DRUG

Interventions

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SLx-2101

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female subjects between 18 and 70 years old, inclusive
* Moderate to severe hypertension
* Body weight within a body mass index of 18-32kg/m2

Exclusion Criteria

* The subject is receiving more than three antihypertensive agents
* A history of drug abuse
* Exposure to a new chemical entity within 3 months prior to the first day of dosing

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No