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Does Inhaled Busedonide or Fluticasone Impair Adrenal Function?

NCT ID: NCT00560625

Last Updated: 2016-09-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-05-31

Study Completion Date

2008-12-31

Brief Summary

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Inhaled corticosteroids are largely used in patients with asthma or chronic obstructive lung diseases. The purpose of this study is to determine if the use of inhaled corticosteroids is associated with suppression of endogenous cortisol production, as seen in patients treated with pharmacologic doses of oral or parenteral steroids.

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Detailed Description

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The normalcy of the hypothalmic-pituitary-adrenal (HPA) axis of enrolled subjects will be assessed by low dose (1mcg) corticotropin (ACTH)stimulation test. Serum cortisol levels will be measured before , 30 minutes and 60 minutes after 1 mcg ACTH intravenous injection.

Conditions

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Adrenal Insufficiency

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* patients receiving inhaled busedonide or fluticasone at daily dose of 200-800 mcg ' for at least 4 weeks

Exclusion Criteria

* patients receiving any corticosteroid therapy, except inhaled busedonide or fluticasone.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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HaEmek Medical Center, Israel

OTHER

Sponsor Role lead

Principal Investigators

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Avraham Ishay, MD

Role: PRINCIPAL_INVESTIGATOR

Endocrine Institute , Haemek Medical Center, Afula. 18101 Israel

Locations

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Endocrine Institute, Haemek medical Center

Afula, , Israel

Site Status

Countries

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Israel

Other Identifiers

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0030-07EMC

Identifier Type: -

Identifier Source: org_study_id

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