Study Of CP-751,871 In Patients With Ewing's Sarcoma Family Of Tumors

NCT ID: NCT00560235

Last Updated: 2015-10-28

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

138 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-03-31

Study Completion Date

2012-10-31

Brief Summary

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Define the efficacy of CP-751,871 in patients with Ewing's sarcoma family of tumors

Detailed Description

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Conditions

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Ewing's Sarcoma Family of Tumors

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

CP-751,871

Intervention Type DRUG

Final dose 30 mg/kg IV on Day 1 of each 28 day cycle until either progression or toxicity

Interventions

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CP-751,871

Final dose 30 mg/kg IV on Day 1 of each 28 day cycle until either progression or toxicity

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Ewing's family of tumors
* Current disease state for which there is no curative therapy

Exclusion Criteria

* Prior anti-IGF-1R therapy
* Concurrent treatment with other anti-cancer agents
Minimum Eligible Age

10 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Tampa, Florida, United States

Site Status

Pfizer Investigational Site

Boston, Massachusetts, United States

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Rochester, Minnesota, United States

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New York, New York, United States

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New York, New York, United States

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Philadelphia, Pennsylvania, United States

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Providence, Rhode Island, United States

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Memphis, Tennessee, United States

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Dallas, Texas, United States

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Seattle, Washington, United States

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Brisbane, Queensland, Australia

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Parkville, Victoria, Australia

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São Paulo, São Paulo, Brazil

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Toronto, Ontario, Canada

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Providencia, Santiago, RM, Chile

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Lille, , France

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Lyon, , France

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Paris, , France

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Villejuif, , France

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Berlin, , Germany

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Freiburg im Breisgau, , Germany

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München, , Germany

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Münster, , Germany

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Jerusalem, , Israel

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Petah Tikva, , Israel

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Bologna, , Italy

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Milan, , Italy

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Torino, , Italy

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Barcelona, Barcelona, Spain

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Esplugues de Llobregat, Barcelona, Spain

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Madrid, Madrid, Spain

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Valencia, Valencia, Spain

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Sutton, Surrey, United Kingdom

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London, , United Kingdom

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London, , United Kingdom

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Pfizer Investigational Site

Oxford, , United Kingdom

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Pfizer Investigational Site

Oxford, , United Kingdom

Site Status

Countries

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United States Australia Brazil Canada Chile France Germany Israel Italy Spain United Kingdom

References

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Juergens H, Daw NC, Geoerger B, Ferrari S, Villarroel M, Aerts I, Whelan J, Dirksen U, Hixon ML, Yin D, Wang T, Green S, Paccagnella L, Gualberto A. Preliminary efficacy of the anti-insulin-like growth factor type 1 receptor antibody figitumumab in patients with refractory Ewing sarcoma. J Clin Oncol. 2011 Dec 1;29(34):4534-40. doi: 10.1200/JCO.2010.33.0670. Epub 2011 Oct 24.

Reference Type DERIVED
PMID: 22025154 (View on PubMed)

Related Links

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https://trialinfoemail.pfizer.com/pages/landing.aspx?StudyID=A4021020

To obtain contact information for a study center near you, click here.

Other Identifiers

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A4021020

Identifier Type: -

Identifier Source: org_study_id

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