The Effect of Rosuvastatin on Adenosine Metabolism

NCT ID: NCT00554138

Last Updated: 2008-09-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-11-30

Study Completion Date

2008-04-30

Brief Summary

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The aim of this study is to show whether rosuvastatin influences adenosine metabolism. Therefore we will determine whether rosuvasatin increases dipyridamole-induced vasodilation by increased adenosine receptor stimulation.

Detailed Description

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Conditions

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Adenosine Metabolism

Keywords

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rosuvastatin dipyridamole caffeine

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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1

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

1 dd for 7-10 days

2

Group Type EXPERIMENTAL

rosuvastatin

Intervention Type DRUG

1 dd 20 mg for 7-10 days

Interventions

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placebo

1 dd for 7-10 days

Intervention Type DRUG

rosuvastatin

1 dd 20 mg for 7-10 days

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* age 18 - 50 years
* Signed informed consent

Exclusion Criteria

* hypertension
* hypercholesterolemia
* diabetes Mellitus
* alanine aminotransferase \> 90 U/L
* creatinine Kinase \> 440 U/L
* cardiovascular disease
* GFR \< 80 ml/min
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Radboud University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Radboud University Nijmegen Medical Centre

Principal Investigators

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Gerard Rongen, MD, PhD

Role: STUDY_DIRECTOR

Radboud University Medical Centre Dep. Pharmacology-Toxicology

Locations

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Radboud University Nijmegen Medical Centre

Nijmegen, , Netherlands

Site Status

Countries

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Netherlands

References

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Meijer P, Oyen WJ, Dekker D, van den Broek PH, Wouters CW, Boerman OC, Scheffer GJ, Smits P, Rongen GA. Rosuvastatin increases extracellular adenosine formation in humans in vivo: a new perspective on cardiovascular protection. Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):963-8. doi: 10.1161/ATVBAHA.108.179622. Epub 2009 Apr 9.

Reference Type DERIVED
PMID: 19359665 (View on PubMed)

Other Identifiers

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Rosudip01

Identifier Type: -

Identifier Source: org_study_id