Double Blind RCT of Bicifadine SR in Outpatients With Chronic Neuropathic Pain Associated With Diabetes

NCT ID: NCT00553592

Last Updated: 2007-11-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

336 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-09-30

Study Completion Date

2008-12-31

Brief Summary

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To compare the efficacy of two dosages (600mg/day and 1200mg/day) of bicifadine SR with placebo for 14 weeks in reduction of chronic neuropathic patin (measured by a daily rating of pain intensity) associated with diabetic periperal neuropathy in adult outpatients.

To compare the tolerability of two dosages of bicifadine SR with placebo in adult outpaitens treated for chronic neuropathic pain for 14 weeks associated with diabetic peripheral neuropathy.

Detailed Description

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Conditions

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Diabetic Peripheral Neuropathy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Drug

Bicifadine

Group Type EXPERIMENTAL

Bicifadine

Intervention Type DRUG

600mg/day

Drug: 2

Bicifadine

Group Type EXPERIMENTAL

Bicifadine

Intervention Type DRUG

1200 mg

Control

Placebo of Bicifadine

Group Type PLACEBO_COMPARATOR

Bicifadine

Intervention Type DRUG

placebo tablet

Interventions

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Bicifadine

600mg/day

Intervention Type DRUG

Bicifadine

placebo tablet

Intervention Type DRUG

Bicifadine

1200 mg

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female, 18 years or older
* Diagnosis of type-1 or type 2 non-insulin dependent diabetes mellitus
* Chronic bilateral pain due to diabetic neuropathy
* Pain for at least six months
* Primary pain is located in the feet
* Others-contact site for information

Exclusion Criteria

* Symptoms of other painful conditions
* Presence of amputations other than toes
* Clinically significant psychiatric or other neurological disorder
* Use of certain medications
* Clinically important other diseases
* Pregnancy
* History of alcohol or narcotic abuse within two years
* Others-contact site for information
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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XTL Biopharmaceuticals

INDUSTRY

Sponsor Role lead

Principal Investigators

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Mark Roffman, PhD

Role: STUDY_DIRECTOR

XTL Bio

Locations

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Four Rivers Clinical Research

Paducah, Kentucky, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Ivy Raso

Role: CONTACT

Phone: 845-267-0707

Email: [email protected]

Kevin Barnes, MT

Role: CONTACT

Phone: 512-306-4254

Email: [email protected]

Facility Contacts

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Jesse Wallace, MD

Role: primary

Caron Massey

Role: backup

Related Links

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http://www.xtlbio.com

Sponsor's website

Other Identifiers

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XTL B07-001

Identifier Type: -

Identifier Source: org_study_id