A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy

NCT ID: NCT00553280

Last Updated: 2021-01-25

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

123 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-02-29

Study Completion Date

2010-01-31

Brief Summary

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The purpose of this study is to assess the safety and efficacy of the long-term use of pregabalin at doses up to 600 mg/day in patients with painful diabetic peripheral neuropathy who have completed 13 weeks of dosing in Study A0081163

Detailed Description

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Conditions

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Diabetic Neuropathy, Painful

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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pregabalin

Group Type EXPERIMENTAL

pregabalin

Intervention Type DRUG

Dosage: 150-600 mg/day (75-300 mg bid), oral administration, Treatment duration: 52 weeks

Interventions

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pregabalin

Dosage: 150-600 mg/day (75-300 mg bid), oral administration, Treatment duration: 52 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients who completed the 13-week treatment of painful diabetic peripheral neuropathy in Study A0081163.
* Patients must be able to understand and cooperate with study procedures and have signed a written informed consent prior to entering the study

Exclusion Criteria

* Patients who experienced serious adverse events in the preceding study (A0081163) that were determined by the investigator or the study sponsor to be causally related to the study medication.
* Patients exhibiting treatment non-compliance in the preceding study (A0081163)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Nagoya, Aichi-ken, Japan

Site Status

Pfizer Investigational Site

Date-shi, Fukushima, Japan

Site Status

Pfizer Investigational Site

Nihommatsu, Fukushima, Japan

Site Status

Pfizer Investigational Site

Shirakawa-shi, Fukushima, Japan

Site Status

Pfizer Investigational Site

Sukagawa, Fukushima, Japan

Site Status

Pfizer Investigational Site

Kamakura, Kanagawa, Japan

Site Status

Pfizer Investigational Site

Yokohama, Kanagawa, Japan

Site Status

Pfizer Investigational Site

Sendai, Miyagi, Japan

Site Status

Pfizer Investigational Site

Matsumoto, Nagano, Japan

Site Status

Pfizer Investigational Site

Ueda, Nagano, Japan

Site Status

Pfizer Investigational Site

Beppu, Oita Prefecture, Japan

Site Status

Pfizer Investigational Site

Yamada, Okayama-ken, Japan

Site Status

Pfizer Investigational Site

Naha, Okinawa, Japan

Site Status

Pfizer Investigational Site

Tomishiro, Okinawa, Japan

Site Status

Pfizer Investigational Site

Urazoe, Okinawa, Japan

Site Status

Pfizer Investigational Site

Hirano-ku, Osaka, Japan

Site Status

Pfizer Investigational Site

Suminoe-ku, Osaka, Japan

Site Status

Pfizer Investigational Site

Sunto-gun, Shizuoka, Japan

Site Status

Pfizer Investigational Site

Oyama-shi, Tochigi, Japan

Site Status

Pfizer Investigational Site

Arakawa City, Tokyo, Japan

Site Status

Pfizer Investigational Site

Bunkyo-ku, Tokyo, Japan

Site Status

Pfizer Investigational Site

Chiyoda-ku, Tokyo, Japan

Site Status

Pfizer Investigational Site

Ohta-ku, Tokyo, Japan

Site Status

Pfizer Investigational Site

Shibuya-ku, Tokyo, Japan

Site Status

Pfizer Investigational Site

Fukuoka, , Japan

Site Status

Pfizer Investigational Site

Ōita, , Japan

Site Status

Pfizer Investigational Site

Tokushima, , Japan

Site Status

Countries

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Japan

References

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Satoh J, Yagihashi S, Baba M, Suzuki M, Arakawa A, Yoshiyama T. Efficacy and safety evaluation of pregabalin treatment over 52 weeks in patients with diabetic neuropathic pain extended after a double-blind placebo-controlled trial. J Diabetes Investig. 2011 Nov 30;2(6):457-63. doi: 10.1111/j.2040-1124.2011.00122.x.

Reference Type DERIVED
PMID: 24843530 (View on PubMed)

Related Links

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Other Identifiers

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A0081164

Identifier Type: -

Identifier Source: org_study_id

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