Effectivity of Dermatix in Promoting Scar Maturation

NCT ID: NCT00548210

Last Updated: 2007-10-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

25 participants

Study Classification

OBSERVATIONAL

Brief Summary

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The purpose of this research is to demonstrate effectivity of Dermatix in promoting maturation of the scar, versus a control region that will be treated with an indifferent cream.

Detailed Description

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The healing of deep thermal injuries is always associated with scarring. The healing process can lead to the formation of large scar bundles (e.g. hypertrophic scars). The scars can be discomforting, disfiguring and restrict motion if situated over or near joints. Evidence for effectivity of treatment for reduction of hypertrophic scars or the prevention of them is limited.

Different treatments are used such as intralesional injected steroids, topically used oily creams, silicone sheets or occlusive dressings. Compression garments are also frequently used. There is some evidence as to the effectivity of silicone sheets for recuction of hypertrophic scarring, however, these sheets cannot be used easily on all anatomical locations.

Valeant Pharmaceuticals International has developed a silicone based scar remodelling gel, Dermatix®, which has been empirically shown by others to have potential to reduce hypertrophic scars.

Primary objectives are to demonstrate effectivity of Dermatix in promoting maturation of the scar, versus a control region that will be treated with an indifferent cream.

Conditions

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Hypertrophic Scars

Keywords

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Hypertrophy scarring scar treatment silicone

Study Design

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Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Patients with hypertrophic scarring and/or ropes, stable for at least 3 months before inclusion.
2. Written informed consent
3. Scar size enabling the definition of two distinct scar areas, with similar scar characteristics at inclusion, preferably symmetric scars.
4. Patients of 18 years or older

Exclusion Criteria

1. Known sensitivity for occlusive dressings or silicone containing products
2. Any patient condition that may influence the compliance of the treatment negatively.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bausch Health Americas, Inc.

INDUSTRY

Sponsor Role collaborator

Association of Dutch Burn Centres

OTHER

Sponsor Role lead

Principal Investigators

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Esther Middelkoop, PhD

Role: STUDY_DIRECTOR

Association of Dutch Burn Centres

Locations

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Association of Dutch Burn Centres

Beverwijk, North Holland, Netherlands

Site Status RECRUITING

Countries

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Netherlands

Central Contacts

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Antoon van den Bogaerdt, PhD

Role: CONTACT

Phone: +31 251 264917

Email: [email protected]

Esther Middelkoop, PhD

Role: CONTACT

Phone: +31 251 265283

Email: [email protected]

Facility Contacts

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Antoon van den Bogaerdt, PhD

Role: primary

Esther Middelkoop, PhD

Role: backup

Other Identifiers

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DERMO0501

Identifier Type: -

Identifier Source: org_study_id