Differential Metabolic Effects of Statins

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Study Classification

OBSERVATIONAL

Study Start Date

2004-01-31

Study Completion Date

2008-03-31

Brief Summary

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The investigators hypothesized simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.

Detailed Description

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Conditions

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Hypercholesterolemia

Keywords

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Lipophilic statins Insulin resistance simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Interventions

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statins (simvastatin, pravastatin)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Low-density lipoprotein cholesterol levels \> 130

Exclusion Criteria

* Overt liver disease,
* Chronic renal failure
* Hypothyroidism
* Myopathy
* Uncontrolled diabetes
* Severe hypertension

Minimum Eligible Age

25 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Kwang K Koh, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

Gachon University Gil Medical Center

Locations

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Gil Medical Center

Incheon, , South Korea

Site Status

Countries

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South Korea

References

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Yada T, Nakata M, Shiraishi T, Kakei M. Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells. Br J Pharmacol. 1999 Mar;126(5):1205-13. doi: 10.1038/sj.bjp.0702397.

Reference Type RESULT

PMID: 10205010 (View on PubMed)

Other Identifiers

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GMC-200406

Identifier Type: -

Identifier Source: org_study_id