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Study of Factors of Genetic Susceptibility Associated to Severe Caries Phenotype

NCT ID: NCT00541060

Last Updated: 2010-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

390 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-10-31

Study Completion Date

2009-11-30

Brief Summary

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Alteration of the post- eruptive enamel microstructure due to a mutation of a gene coding for a matrix protein could increase the susceptibility of the enamel to caries after tooth eruption. To identify in young patients with severe caries incidence, the occurrence of mutations in several candidate genes which result in an alteration of the enamel microstructure that could explain the high caries susceptibility of the patient.

Detailed Description

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Although its prevalence has decreased dramatically in European countries, dental caries remains a burden for the society and especially for certain groups of the population. For example, 80% of the carious lesions are diagnosed in about 20% of the children. For years, the aetiology of this disease has been mainly related to environmental factors but recent data support the possibility of a human genetic contribution. Alteration of the post- eruptive enamel microstructure due to a mutation of a gene coding for a matrix protein could increase the susceptibility of the enamel to caries after tooth eruption. The main objective of this study will be to identify in young patients with severe caries incidence, the occurrence of mutations in several candidate genes which result in an alteration of the enamel microstructure that could explain the high caries susceptibility of the patient. With this aim, we will carry out a case- control multicentre European study on 250 young patients presenting several carious lesions and 160 young adults totally caries free. Patients with systemic or enamel pathologies such as amelogenesis imperfecta will not be included in the study. The study will consist of 2 visits, 1: inclusion and genetic test based on a salivary sample and 2: after 6 months, communication of the genetic test result to the patient and his parents. The main evaluation criteria will be the finding of a mutation on the candidates genes not resulting in an amelogenesis imperfecta phenotype but associated to a severe caries phenotype. If a direct relation between a mutation and a severe caries phenotype was shown, all the classical approaches, prevention protocols and treatments of caries would need to be reconsidered.

Conditions

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Dental Caries

Keywords

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caries susceptibility,enamel matrix,candidate genes,mutation

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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A

250 young patients presenting several carious lesions

Group Type ACTIVE_COMPARATOR

mutation

Intervention Type GENETIC

a mutation of a gene coding

B

160 young adults totally caries free

Group Type PLACEBO_COMPARATOR

mutation

Intervention Type GENETIC

a mutation of a gene coding

Interventions

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mutation

a mutation of a gene coding

Intervention Type GENETIC

Other Intervention Names

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a mutation of a gene coding

Eligibility Criteria

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Inclusion Criteria

* Patients : presenting at least 3 active carious lesions aged 2 to 16 years old, written informed consent
* Volunteers : young adults 18 to 30 years old totally caries free

Exclusion Criteria

* patients with systemic or enamel pathologies such as amelogenesis imperfecta
* osteogenesis imperfecta
* hypophosphatemia
* hypodermal dysplasia
* syndrome of Prader Willi
* Fluoroses
* toxic enamel dysplasia
* pregnancy or breast-feeding
* HYPOSIALORRHEA
* immunodepression status
* chronicle diseases
* anorexia or bulimia
Minimum Eligible Age

2 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role lead

Responsible Party

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Department of Clinical Research of developpement

Principal Investigators

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Catherine Miller, MCU-PH

Role: STUDY_DIRECTOR

Assistance Publique - Hôpitaux de Paris

Locations

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Hopital Bretonneau

Paris, , France

Site Status

Countries

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France

Other Identifiers

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P061009

Identifier Type: -

Identifier Source: org_study_id