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Risk Factors for Recurrent Urinary Tract Infection in Children

NCT ID: NCT00528476

Last Updated: 2007-09-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

161 participants

Study Classification

OBSERVATIONAL

Study Start Date

2004-11-30

Study Completion Date

2007-01-31

Brief Summary

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The purpose of this study is to determine clinical and urodynamic risk factors for recurrent urinary tract infection in 5-18 years old children.

Detailed Description

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It is known, that in the group of young children the most common reason of recurrent UTI is anatomic abnormalities, such as vesicoureteral reflux, hydronephrosis. However, not all recurrent UTI can be explained by anatomic abnormalities. The vast majority of school age children with recurrent UTI have anatomically normal urinary tract. Recent studies discuss about the role of behavioral and functional abnormalities (inadequate fluid intake, stool retention, infrequent voiding, etc.) that can predispose recurrent urinary tract infections. Influence of some these abnormalities for recurrent UTI is controversial. Family history, behavioral and functional abnormalities which predispose to urinary tract infections in children with normal urinary tract are neglected in most protocols of urinary tract infection.

Children in this study receive a careful evaluation including complete history, voiding-drinking diary, bowel questionnaire, physical investigation, sonography, voiding cystourethrogram.

Follow up time - 1 year. Urinalysis once a month and during each episode of fever.

Conditions

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Urinary Tract Infection Pyelonephritis Cystitis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Patients, who were treated because of recurrent (2 or more urinary tract infections per year) pyelonephritis or cystitis.

No interventions assigned to this group

2

Patients with nonrecurrent urinary tract infections (patients who had no history of more than one urinary tract infections in last year).

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* 5-18 years old children, who were treated because of cystitis and pyelonephritis in Kaunas Medical University Hospital

Exclusion Criteria

* urinary tract malformations
* neurogenic bladder dysfunction
* patients, who received immunosuppressive drugs
* pregnant girls
* children with non bacterial urinary tract infection
Minimum Eligible Age

5 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kaunas University of Medicine

OTHER

Sponsor Role lead

Principal Investigators

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Sarunas Rudaitis, MD

Role: PRINCIPAL_INVESTIGATOR

Clinic of Children's Diseases, Kaunas University of Medicine

Birute Pundziene, MD, PhD

Role: STUDY_CHAIR

Clinic of Children's Diseases, Kaunas University of Medicine

Locations

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Kaunas University of Medicine

Kaunas, , Lithuania

Site Status

Countries

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Lithuania

Other Identifiers

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BE-2-68

Identifier Type: -

Identifier Source: org_study_id