Pulse Corticosteroid Therapy and Effect on Brain Water Diffusivity
NCT ID: NCT00527176
Last Updated: 2007-09-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
OBSERVATIONAL
2007-09-30
2007-09-30
Brief Summary
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The relative proportion of those two components are not known, as well their kinetics.
Diffusion Weighted Imaging ( DWI) is a none invasive and none toxic technique to study those phenomena.We can also study the diffusivity anisotropy not using a Gaussian distribution but rather a non- gaussian one, more close to the reality ( q Space Imaging ).
Finally, we can study the compartment redistribution between slow and rapid water molecules diffusion by bi-exponential decomposition of the diffusion signal, corresponding, theorically, respectively to the intra- and extra-cellular component.
Hypothesis : The high dosis steroid pulse therapy modifies or not the water free diffusion in DWI and qSI ? Is there a modification in the diffusivity of both rapid and slow component ?
Detailed Description
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Conditions
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Study Design
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DEFINED_POPULATION
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* normal neurological exam
* informed consent
* 18 yo or more
Exclusion Criteria
* younger than 18 years old
18 Years
ALL
No
Sponsors
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Fonds National de la Recherche Scientifique
OTHER
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
OTHER
Principal Investigators
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Thierry Duprez, MD
Role: STUDY_DIRECTOR
UNIVERSITE CATHOLIQUE DE LOUVAIN
Denis Rommel, MD
Role: PRINCIPAL_INVESTIGATOR
UNIVERSITE CATHOLIQUE DE LOUVAIN
Locations
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Clinique Universitaire St LUC
Brussels, , Belgium
Countries
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Central Contacts
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References
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Bosma GP, Huizinga TW, Mooijaart SP, Van Buchem MA. Abnormal brain diffusivity in patients with neuropsychiatric systemic lupus erythematosus. AJNR Am J Neuroradiol. 2003 May;24(5):850-4.
Moritani T, Shrier DA, Numaguchi Y, Takahashi C, Yano T, Nakai K, Zhong J, Wang HZ, Shibata DK, Naselli SM. Diffusion-weighted echo-planar MR imaging of CNS involvement in systemic lupus erythematosus. Acad Radiol. 2001 Aug;8(8):741-53. doi: 10.1016/S1076-6332(03)80581-0.
Steens SC, Steup-Beekman GM, Bosma GP, Admiraal-Behloul F, Olofsen H, Doornbos J, Huizinga TW, van Buchem MA. The effect of corticosteroid medication on quantitative MR parameters of the brain. AJNR Am J Neuroradiol. 2005 Nov-Dec;26(10):2475-80.
Dehmeshki J, Van Buchem MA, Bosma GP, Huizinga TW, Tofts PS. Systemic lupus erythematosus: diagnostic application of magnetization transfer ratio histograms in patients with neuropsychiatric symptoms--initial results. Radiology. 2002 Mar;222(3):722-8. doi: 10.1148/radiol.2223010413.
Peterson PL, Howe FA, Clark CA, Axford JS. Quantitative magnetic resonance imaging in neuropsychiatric systemic lupus erythematosus. Lupus. 2003;12(12):897-902. doi: 10.1191/0961203303lu499oa.
Moritani T, Hiwatashi A, Shrier DA, Wang HZ, Numaguchi Y, Westesson PL. CNS vasculitis and vasculopathy: efficacy and usefulness of diffusion-weighted echoplanar MR imaging. Clin Imaging. 2004 Jul-Aug;28(4):261-70. doi: 10.1016/S0899-7071(03)00191-8.
Sun SS, Huang WS, Chen JJ, Chang CP, Kao CH, Wang JJ. Evaluation of the effects of methylprednisolone pulse therapy in patients with systemic lupus erythematosus with brain involvement by Tc-99m HMPAO brain SPECT. Eur Radiol. 2004 Jul;14(7):1311-5. doi: 10.1007/s00330-003-2166-3. Epub 2003 Dec 9.
Other Identifiers
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B40320072108
Identifier Type: -
Identifier Source: org_study_id