High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Newly Diagnosed Stage I, Stage II, or Stage III Multiple Myeloma

NCT ID: NCT00526734

Last Updated: 2013-08-12

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 100 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2006-02-28

Brief Summary

RATIONALE: Drugs used in chemotherapy, such as melphalan, use different ways to stop cancer cells from dividing so they stop growing or die. Stem cell transplant using stem cells from the patient may be able to replace immune cells that were destroyed by chemotherapy used to kill cancer cells. Giving colony-stimulating factors, such as G-CSF or pegfilgrastim, helps stem cells move from the bone marrow to the blood so they can be collected. It is not yet known which regimen is more effective in treating multiple myeloma.

PURPOSE: This randomized phase II trial is studying how well high-dose chemotherapy followed by stem cell transplant works in treating patients with newly diagnosed stage I, stage II, or stage III multiple myeloma.

Detailed Description

OBJECTIVES:

Primary

• Compare engraftment of peripheral blood progenitor cells (PBPCs) mobilized by 2 different fixed doses of pegfilgrastim versus a by-weight dose of filgrastim (G-CSF).

Secondary

• Determine the ability of 2 different fixed doses of pegfilgrastim to mobilize PBPCs.
• Determine the safety of pegfilgrastim during PBPC mobilization and collection.
• Determine the effect of different induction chemotherapy regimens on autologous progenitor cell transplantation.

OUTLINE: This is a multicenter study. Patients are stratified by type of induction chemotherapy (Thal/Dex vs VAD vs Vel-Dex vs VTD) and by stage of disease according to International Prognostic Index criteria (stage I [i.e., beta-2 microglobulin < 3.5 and albumin > 35] vs stages II and III).

• Induction therapy: Patients receive 3-4 courses of 1 of the following regimens:

• VAD: Patients receive vincristine, doxorubicin hydrochloride, and dexamethasone.
• Thal/Dex: Patients receive thalidomide and dexamethasone.
• Vel-Dex: Patients receive bortezomib and dexamethasone.
• VTD: Patients receive bortezomib, thalidomide, and dexamethasone. Patients achieving complete, partial, or minimal response after 3-4 courses of induction therapy proceed to peripheral blood progenitor cell (PBPC) mobilization 17 days after completion of induction therapy.
• PBPC mobilization: Patients are randomized to 1 of 3 arms.

• Arm I: Patients receive filgrastim subcutaneously (SC) once daily until the final leukapheresis.
• Arm II: Patients receive a single dose of pegfilgrastim SC.
• Arm III: Patients receive pegfilgrastim as in arm II at a higher dose.
• Leukapheresis: Patients undergo up to 3 leukaphereses to obtain adequate numbers of CD34-positive filgrastim- or pegfilgrastim-mobilized PBPCs for engraftment. Patients achieving a sufficient number of collected PBSCs proceed to conditioning chemotherapy.
• Conditioning chemotherapy: Patients receive high-dose melphalan* IV over 1-2 days. Patients then proceed to PBPC transplantation.

NOTE: *Patients ≥ 65 years old receive melphalan at a lower dose.

• Autologous PBPC transplantation: Patients undergo infusion of PBPCs on day 0. Patients in all arms receive G-CSF support beginning on day 1 after PBPC transplantation and continuing until blood counts recover for 3 consecutive days.

After completion of study therapy, patients are followed for up to 100 days post-transplantation.

Conditions

Multiple Myeloma and Plasma Cell Neoplasm

Keywords

stage I multiple myeloma; stage II multiple myeloma; stage III multiple myeloma

Study Design

• Allocation Method: RANDOMIZED
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Interventions

filgrastim

Intervention Type: BIOLOGICAL

pegfilgrastim

Intervention Type: BIOLOGICAL

melphalan

Intervention Type: DRUG

autologous hematopoietic stem cell transplantation

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• ECOG performance status 0-2
• ANC ≥ 1.0 x 10^9/L (without colony-stimulating factors)
• Platelet count ≥ 50 x 10^9/L (without transfusion support within the past 7 days)
• Serum calcium < 14 mg/dL
• AST and ALT ≤ 2.5 times upper limit of normal (ULN)
• Total bilirubin ≤ 1.5 times ULN
• Creatinine clearance ≥ 50 mL/min
• Fertile patients must use effective contraception
• Negative pregnancy test
• Willing and able to comply with protocol requirements

Exclusion Criteria

• Myocardial infarction within the past 6 months
• New York Heart Association class III or IV heart failure
• Uncontrolled angina
• Severe uncontrolled ventricular arrhythmia
• Acute ischemia or active conduction system abnormalities as evidenced by ECG
• Serious medical condition that could prolong hematological recovery or preclude completion of or tolerance to protocol therapy
• Seropositive for HIV antibody
• Known hepatitis B surface antigen positivity OR active hepatitis C infection
• Active systemic infection requiring treatment
• Pregnant or nursing
• Poor psychiatric condition

PRIOR CONCURRENT THERAPY:

• No plasmapheresis within the past 4 weeks
• No major surgery within the past 4 weeks
• No anticancer therapy within the past 5 years, except treatment for basal cell carcinoma of the skin or carcinoma in situ of the uterine cervix
• No other concurrent G-CSF growth factors
• No concurrent enrollment in another investigational clinical trial
• No concurrent investigational agent that would contraindicate the use of pegfilgrastim as either a mobilization agent or a hematological recovery agent

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Erasme University Hospital

OTHER

Sponsor Role: lead

Principal Investigators

Walter Feremans, MD, PhD

Role: STUDY_CHAIR

Erasme University Hospital

Locations

Hopital Universitaire Erasme

Brussels, , Belgium

Site Status: RECRUITING

Medical University of Gdansk

Gdansk, , Poland

Site Status: RECRUITING

Silesian Medical Academy

Katowice, , Poland

Site Status: RECRUITING

Institute of Haematology and Blood Transfusion

Warsaw, , Poland

Site Status: RECRUITING

Countries

Belgium; Poland

Facility Contacts

Walter Feremans, MD, PhD

Role: primary

Andrzej W. Hellmann, MD, PhD

Role: primary

Jerzy Holowiecki, MD, PhD

Role: primary

Krzysztof Warzocha, MD, PhD

Role: primary

Other Identifiers

CDR0000561733

Identifier Type: REGISTRY

Identifier Source: secondary_id

ERA-NEUMOBIL

Identifier Type: -

Identifier Source: secondary_id

EUDRACT-2006-000891-34

Identifier Type: -

Identifier Source: secondary_id

ERA-2006-001

Identifier Type: -

Identifier Source: org_study_id