Assessment of the Reactogenicity of ADACEL® (TdcP Vaccine) in Children and Adolescents 7 to 19 Years of Age

NCT ID: NCT00524732

Last Updated: 2014-01-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

7156 participants

Study Classification

OBSERVATIONAL

Study Start Date

2004-09-30

Study Completion Date

2005-09-30

Brief Summary

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To compare the reactogenicity of ADACEL® vaccine given at intervals of 2 to 9 years with the reactogenicity of ADACEL® vaccine given at an interval of 10 or more years following the last previous administration of vaccine containing Diphtheria and Tetanus Toxoids (referred to as TD/Td).

Detailed Description

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Conditions

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Pertussis Diphtheria

Study Design

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Study Time Perspective

CROSS_SECTIONAL

Study Groups

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1

18 to 30 months since last prior dose of TD/Td vaccine.

Tetanus and diphtheria toxoids and acellular pertussis

Intervention Type BIOLOGICAL

0.5 mL, Intramuscular

2

30 to 42 months since last prior dose of TD/Td vaccine.

Tetanus and diphtheria toxoids and acellular pertussis

Intervention Type BIOLOGICAL

0.5 mL, Intramuscular

3

42 to 54 months since last prior dose of TD/Td vaccine.

Tetanus and diphtheria toxoids and acellular pertussis

Intervention Type BIOLOGICAL

0.5 mL, Intramuscular

4

54 to 66 months since last prior dose of TD/Td vaccine.

Tetanus and diphtheria toxoids and acellular pertussis

Intervention Type BIOLOGICAL

0.5 mL, Intramuscular

5

66 to 78 months since last prior dose of TD/Td vaccine.

Tetanus and diphtheria toxoids and acellular pertussis

Intervention Type BIOLOGICAL

0.5 mL, Intramuscular

6

78 to 90 months since last prior dose of TD/Td vaccine.

Tetanus and diphtheria toxoids and acellular pertussis

Intervention Type BIOLOGICAL

0.5 mL, Intramuscular

7

90 to 102 months since last prior dose of TD/Td vaccine.

Tetanus and diphtheria toxoids and acellular pertussis

Intervention Type BIOLOGICAL

0.5 mL, Intramuscular

8

102 to 114 months since last prior dose of TD/Td vaccine.

Tetanus and diphtheria toxoids and acellular pertussis

Intervention Type BIOLOGICAL

0.5 mL, Intramuscular

9

Control - over 114 months since last prior dose of TD/Td vaccine.

Tetanus and diphtheria toxoids and acellular pertussis

Intervention Type BIOLOGICAL

0.5 mL, Intramuscular

Interventions

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Tetanus and diphtheria toxoids and acellular pertussis

0.5 mL, Intramuscular

Intervention Type BIOLOGICAL

Other Intervention Names

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ADACEL®

Eligibility Criteria

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Inclusion Criteria

* Age \> 7 years and \< 20 years.
* Signed and dated IRB-approved informed consent form obtained from the participant, parent or legal guardian prior to the first study intervention.
* Judged to be in good health on the basis of reported medical history.
* Available for planned length of the study.
* Participant or parent or legal guardian (as applicable) can read and write English and can understand the informed consent documents and the study instructions.

A participant eleven years of age or older who meets an exclusion criterion may not be enrolled in the study but nonetheless may participate in the vaccination program, at the discretion of the Prince Edward Island public health authorities).

A participant younger than eleven years of age who meets an exclusion criterion may not be enrolled in the study and may not participate in the vaccination program.

Exclusion Criteria

* Known or suspected allergy to ADACEL®, any of the vaccine's components, or prior allergic reaction to Diphtheria or Tetanus Toxoids or Acellular Pertussis Vaccine.
* Planned receipt of any other vaccine within the 14 days following administration of ADACEL® vaccine in this study.
* Any other medical condition that in the opinion of the investigator would cause an unexpected hazard or interfere with the study objective.
* Receipt of TD/Td within the preceding 12 months.
* Known or suspected to be pregnant.

A participant eleven years of age or older who meets an exclusion criterion may not be enrolled in the study but nonetheless may participate in the vaccination program, at the discretion of the Prince Edward Island public health authorities).

A participant younger than eleven years of age who meets an exclusion criterion may not be enrolled in the study and may not participate in the vaccination program.
Minimum Eligible Age

7 Years

Maximum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sanofi Pasteur, a Sanofi Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Director

Role: STUDY_DIRECTOR

Sanofi Pasteur Inc.

Locations

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Halifax, Nova Scotia, Canada

Site Status

Charlottetown, , Canada

Site Status

Countries

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Canada

References

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Halperin SA, Sweet L, Baxendale D, Neatby A, Rykers P, Smith B, Zelman M, Maus D, Lavigne P, Decker MD. How soon after a prior tetanus-diphtheria vaccination can one give adult formulation tetanus-diphtheria-acellular pertussis vaccine? Pediatr Infect Dis J. 2006 Mar;25(3):195-200. doi: 10.1097/01.inf.0000202082.56403.c4.

Reference Type RESULT
PMID: 16511379 (View on PubMed)

Related Links

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Other Identifiers

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TD511

Identifier Type: -

Identifier Source: org_study_id

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