Correlation Salivary Cortisol and Free Serum Cortisol to Total Serum Cortisol in MICU Septic Shock
NCT ID: NCT00523198
Last Updated: 2014-12-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
60 participants
OBSERVATIONAL
2007-02-28
2008-10-31
Brief Summary
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* to correlate salivary cortisol to free serum cortisol (as salivary cortisol is considered to be almost complete free cortisol) and,
* to correlate free serum cortisol to total serum cortisol levels
Both in patients with septic shock (severe sepsis requiring vasopressors).
We believe that:
* total serum cortisol does not correlate with free serum cortisol in patient with septic shock and,
* that salivary cortisol correlates with free serum cortisol and can be used to determine the level of free serum cortisol.
Detailed Description
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In patients with septic shock only the total serum cortisol level is available, however, the free cortisol level can be normal despite a low total cortisol level due to changes in the serum protein.
The hormone can be replaced improperly in these patients and contribute to poor outcome in septic shock.
We are studying adult MICU patients with septic shock who are not receiving corticosteroid replacement.
This study does not include any intervention.
In-hospital or 28-day mortality are registered in all the patients.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Blood in mouth
18 Years
ALL
No
Sponsors
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The University of Texas Health Science Center, Houston
OTHER
Responsible Party
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Rosa Estrada Y Martin
Associate Professor
Principal Investigators
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Rosa M Estrada-Y-Martin, MD
Role: PRINCIPAL_INVESTIGATOR
The University of Texas-Health Science Center at Houston / Division of Pulmonary, Sleep and Critical Care Medicine
Locations
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The University of Texas- Health Science Center at Houston
Houston, Texas, United States
Countries
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References
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Estrada-Y-Martin RM, Orlander PR. Salivary cortisol can replace free serum cortisol measurements in patients with septic shock. Chest. 2011 Nov;140(5):1216-1222. doi: 10.1378/chest.11-0448. Epub 2011 Aug 4.
Other Identifiers
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M01-RR 02558 (GCRC)
Identifier Type: OTHER
Identifier Source: secondary_id
HSC-MS-06-413
Identifier Type: -
Identifier Source: org_study_id