A Comparison of Lorazepam and Diazepam in the Treatment of Alcohol Withdrawal
NCT ID: NCT00523185
Last Updated: 2007-08-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
55 participants
INTERVENTIONAL
2003-05-31
2004-11-30
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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2
Diazepam
Diazepam 20 mg by mouth every two hours x 3 doses, or for parenteral treatment, diazepam 10 mg intravenously every one hour x 6 doses. Give additional diazepam 10 mg by mouth or intravenously every two hours as needed for alcohol withdrawal symptoms.
1
Lorazepam
Lorazepam 1 to 2 mg by mouth or intravenously every two hours as needed for alcohol withdrawal symptoms.
Interventions
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Lorazepam
Lorazepam 1 to 2 mg by mouth or intravenously every two hours as needed for alcohol withdrawal symptoms.
Diazepam
Diazepam 20 mg by mouth every two hours x 3 doses, or for parenteral treatment, diazepam 10 mg intravenously every one hour x 6 doses. Give additional diazepam 10 mg by mouth or intravenously every two hours as needed for alcohol withdrawal symptoms.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* History of alcohol use within 24 hours
* Ability to consent to participate in the study
Exclusion Criteria
* Active abuse of other CNS depressants
* Acute intoxication with a CNS activating agent
* Severe hepatic dysfunction
* Pregnancy
* History of dementia
19 Years
ALL
No
Sponsors
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Stanford University
OTHER
Principal Investigators
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Jose R Maldonado, MD
Role: PRINCIPAL_INVESTIGATOR
Stanford University
Locations
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Palo Alto Veterans Affairs Hospital System
Palo Alto, California, United States
Stanford Hospital and Clinics
Stanford, California, United States
Countries
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References
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Maldonado JR, Nguyen LH, Schader EM, Brooks JO 3rd. Benzodiazepine loading versus symptom-triggered treatment of alcohol withdrawal: a prospective, randomized clinical trial. Gen Hosp Psychiatry. 2012 Nov-Dec;34(6):611-7. doi: 10.1016/j.genhosppsych.2012.06.016. Epub 2012 Aug 13.
Other Identifiers
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77757
Identifier Type: -
Identifier Source: org_study_id