Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure

NCT ID: NCT00517725

Last Updated: 2010-09-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-07-31

Study Completion Date

2010-05-31

Brief Summary

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The investigators test the hypothesis that different beta-blockers had a different influence on chemoreceptor response and lung diffusion capacity.

Both could influence exercise capacity in normoxic as well as hypoxic conditions.

Detailed Description

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Conditions

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Chronic Heart Failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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Carvedilol

Group Type ACTIVE_COMPARATOR

carvedilol

Intervention Type DRUG

Bisoprolol

Group Type ACTIVE_COMPARATOR

bisoprolol

Intervention Type DRUG

Nebivolol

Group Type ACTIVE_COMPARATOR

Nebivolol

Intervention Type DRUG

Interventions

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carvedilol

Intervention Type DRUG

bisoprolol

Intervention Type DRUG

Nebivolol

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Chronic heart failure patients in stable clinical condition

Exclusion Criteria

* No comorbidity
* NYHA class IV
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centro Cardiologico Monzino

OTHER

Sponsor Role lead

Responsible Party

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Centro Cardiologico Monzino - Univeristy of Milan

Principal Investigators

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Piergiuseppe Agostoni, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Centro Cardiologico Monzino

Giancarlo Marenzi, MD

Role: STUDY_CHAIR

Centro Cardiologico Monzino

Locations

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Centro Cardiologico Monzino, University of Milan

Milan, , Italy

Site Status

Countries

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Italy

References

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Agostoni P, Bussotti M, Cattadori G, Margutti E, Contini M, Muratori M, Marenzi G, Fiorentini C. Gas diffusion and alveolar-capillary unit in chronic heart failure. Eur Heart J. 2006 Nov;27(21):2538-43. doi: 10.1093/eurheartj/ehl302. Epub 2006 Oct 6.

Reference Type BACKGROUND
PMID: 17028107 (View on PubMed)

Karsten M, Contini M, Cefalu C, Cattadori G, Palermo P, Apostolo A, Bussotti M, Magri D, Salvioni E, Farina S, Sciomer S, Catai AM, Agostoni P. Effects of carvedilol on oxygen uptake and heart rate kinetics in patients with chronic heart failure at simulated altitude. Eur J Prev Cardiol. 2012 Jun;19(3):444-51. doi: 10.1177/1741826711402736. Epub 2011 Mar 7.

Reference Type DERIVED
PMID: 21450573 (View on PubMed)

Other Identifiers

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R76-CCM S78/407

Identifier Type: -

Identifier Source: org_study_id